Inflammatory networks underlying colorectal cancer

被引：423

作者：

Lasry, Audrey ^{[1
]}

Zinger, Adar ^{[1
]}

Ben-Neriah, Yinon ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Sch Med, Inst Med Res Israel Canada, Lautenberg Ctr Immunol & Canc Res, IL-91010 Jerusalem, Israel

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 03期

基金：

以色列科学基金会; 欧洲研究理事会;

关键词：

ANTI-TNF THERAPY; GENOME-WIDE ASSOCIATION; KAPPA-B ACTIVATION; ASPIRIN USE; I INTERFERON; BARRIER DYSFUNCTION; LYMPHOID STRUCTURES; INTESTINAL BARRIER; TUMOR INITIATION; MISMATCH-REPAIR;

D O I：

10.1038/ni.3384

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammation is emerging as one of the hallmarks of cancer, yet its role in most tumors remains unclear. Whereas a minority of solid tumors are associated with overt inflammation, long-term treatment with non-steroidal anti-inflammatory drugs is remarkably effective in reducing cancer rate and death. This indicates that inflammation might have many as-yet-unrecognized facets, among which an indolent course might be far more prevalent than previously appreciated. In this Review, we explore the various inflammatory processes underlying the development and progression of colorectal cancer and discuss anti-inflammatory means for its prevention and treatment.

引用

页码：230 / 240

页数：11

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