Nanoscaled porphyrinic metal-organic frameworks: photosensitizer delivery systems for photodynamic therapy

被引：64

作者：

Buzek, Daniel ^{[1
,2
]}

Zelenka, Jaroslav ^{[3
]}

Ulbrich, Pavel ^{[3
]}

Ruml, Tomas ^{[3
]}

Krizova, Ivana ^{[3
]}

Lang, Jan ^{[4
]}

Kubat, Pavel ^{[5
]}

Demel, Jan ^{[1
]}

Kirakci, Kaplan ^{[1
]}

Lang, Kamil ^{[1
]}

机构：

[1] Czech Acad Sci, Vvi, Inst Inorgan Chem, Husinec Rez 1001, Rez 25068, Czech Republic

[2] Univ JE Purkyne, Fac Environm, Kralova Vysina 3132-7, Usti Nad Labem 40096, Czech Republic

[3] Univ Chem & Technol, Prague 16628, Czech Republic

[4] Charles Univ Prague, Fac Math & Phys, V Holesovickach 2, Prague 18000 8, Czech Republic

[5] Czech Acad Sci Vvi, J Heyrovsky Inst Phys Chem, Vvi, Dolejskova 3, Prague 18223 8, Czech Republic

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 09期

关键词：

NANOCRYSTALS; SIMULANT; DESIGN; CANCER;

D O I：

10.1039/c6tb03230c

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The photocytotoxic activity of porphyrin-containing materials including metal-organic frameworks (MOFs) has attracted ever increasing interest. We have developed a simple synthesis of hexagonal PCN-222/MOF-545 nanoparticles, which are powerful in inducing reactive oxygen species-mediated apoptosis of cancer cells upon visible light irradiation. The extent of the cytotoxic effect well correlates with the nanoparticle size and structural instability. High phototoxicity of the presented nanoparticles and their deactivation within several hours open up the door to possible applications in cancer therapy.

引用

页码：1815 / 1821

页数：7

共 25 条

[1] Zr-based metal-organic frameworks: design, synthesis, structure, and applications [J].

Bai, Yan ;

Dou, Yibo ;

Xie, Lin-Hua ;

Rutledge, William ;

Li, Jian-Rong ;

Zhou, Hong-Cai .

CHEMICAL SOCIETY REVIEWS, 2016, 45 (08) :2327-2367

[2] Photosensitized oxidation of 2′,7′-dichlorofluorescin:: Singlet oxygen does not contribute to the formation of fluorescent oxidation product 2′,7′-dichlorofluorescein [J].

Bilski, P ;

Belanger, AG ;

Chignell, CF .

FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 (07) :938-946

[3] Planar Heterojunction Perovskite Solar Cells Incorporating Metal-Organic Framework Nanocrystals [J].

Chang, Ting-Hsiang ;

Kung, Chung-Wei ;

Chen, Hsin-Wei ;

Huang, Tzu-Yen ;

Kao, Sheng-Yuan ;

Lu, Hsin-Che ;

Lee, Min-Han ;

Boopathi, Karunakara Moorthy ;

Chu, Chih-Wei ;

Ho, Kuo-Chuan .

ADVANCED MATERIALS, 2015, 27 (44) :7229-+

[4] Functional Nanomaterials for Phototherapies of Cancer [J].

Cheng, Liang ;

Wang, Chao ;

Feng, Liangzhu ;

Yang, Kai ;

Liu, Zhuang .

CHEMICAL REVIEWS, 2014, 114 (21) :10869-10939

[5] A distinct reversible colorimetric and fluorescent low pH response on a water-stable zirconium-porphyrin metal-organic framework [J].

Deibert, Benjamin J. ;

Li, Jing .

CHEMICAL COMMUNICATIONS, 2014, 50 (68) :9636-9639

[6] Modular chemistry: Secondary building units as a basis for the design of highly porous and robust metal-organic carboxylate frameworks [J].

Eddaoudi, M ;

Moler, DB ;

Li, HL ;

Chen, BL ;

Reineke, TM ;

O'Keeffe, M ;

Yaghi, OM .

ACCOUNTS OF CHEMICAL RESEARCH, 2001, 34 (04) :319-330

[7] Construction of Ultrastable Porphyrin Zr Metal-Organic Frameworks through Linker Elimination [J].

Feng, Dawei ;

Chung, Wan-Chun ;

Wei, Zhangwen ;

Gu, Zhi-Yuan ;

Jiang, Hai-Long ;

Chen, Ying-Pin ;

Darensbourg, Donald J. ;

Zhou, Hong-Cai .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (45) :17105-17110

[8] Zirconium-Metalloporphyrin PCN-222: Mesoporous Metal-Organic Frameworks with Ultrahigh Stability as Biomimetic Catalysts [J].

Feng, Dawei ;

Gu, Zhi-Yuan ;

Li, Jian-Rong ;

Jiang, Hai-Long ;

Wei, Zhangwen ;

Zhou, Hong-Cai .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (41) :10307-10310

[9] Metal-metalloporphyrin frameworks: a resurging class of functional materials [J].

Gao, Wen-Yang ;

Chrzanowski, Matthew ;

Ma, Shengqian .

CHEMICAL SOCIETY REVIEWS, 2014, 43 (16) :5841-5866

[10] Ultralow-Power Near Infrared Lamp Light Operable Targeted Organic Nanoparticle Photodynamic Therapy [J].

Huang, Ling ;

Li, Zhanjun ;

Zhao, Yang ;

Zhang, Yuanwei ;

Wu, Shuang ;

Zhao, Jianzhang ;

Han, Gang .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (44) :14586-14591

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