Kidney Organoids: A Translational Journey

被引：104

作者：

Morizane, Ryuji ^{[1
,2
,3
]}

Bonventre, Joseph V. ^{[1
,2
,3
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, Div Renal, 75 Francis St, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Med, Boston, MA USA

[3] Harvard Stem Cell Inst, Cambridge, MA USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2017年 / 23卷 / 03期

基金：

美国国家卫生研究院;

关键词：

PLURIPOTENT STEM-CELLS; IN-VITRO EXPANSION; INTERMEDIATE MESODERM; EPITHELIAL-CELLS; DIRECTED DIFFERENTIATION; PROGENITOR CELLS; URETERAL BUD; LONG-TERM; LINEAGE SPECIFICATION; NEPHRON PROGENITORS;

D O I：

10.1016/j.molmed.2017.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human pluripotent stem cells (hPSCs) are attractive sources for regenerative medicine and disease modeling in vitro. Directed hPSC differentiation approaches have derived from knowledge of cell development in vivo rather than from stochastic cell differentiation. Moreover, there has been great success in the generation of 3D organ-buds termed 'organoids' from hPSCs; these consist of a variety of cell types in vitro that mimic organs in vivo. The organoid bears great potential in the study of human diseases in vitro, especially when combined with CRISPR/Cas9-based genome-editing. We summarize the current literature describing organoid studies with a special focus on kidney organoids, and discuss goals and future opportunities for organoid-based studies.

引用

页码：246 / 263

页数：18

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