Association of serum organochlorine pesticides concentrations with reproductive hormone levels and polycystic ovary syndrome in a Chinese population

被引：17
|
作者：
Guo, Zhizhun [1 ]
Qiu, Huiling [2 ]
Wang, Lingling [2 ]
Wang, Lijun [2 ]
Wang, Chonggang [1 ,3 ]
Chen, Meng [3 ]
Zuo, Zhenghong [1 ,3 ]
机构：
[1] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Peoples R China
[2] Xiamen Univ, Affiliated Chenggong Hosp, Dept Gynaecol, Xiamen 361002, Peoples R China
[3] Xiamen Univ, Minist Educ Subtrop Wetland Ecosyst Res, Key Lab, Xiamen 361102, Peoples R China
来源：
CHEMOSPHERE | 2017年 / 171卷
关键词：
Polycystic ovary syndrome; Organochlorine pesticides; Endocrine disrupting; Serum; ENDOCRINE-DISRUPTING CHEMICALS; MALARIA VECTOR-CONTROL; BISPHENOL-A; NEONATAL EXPOSURE; RISK-ASSESSMENT; DDT; PARAMETERS; ESTROGENS; O; P'-DDT; PCOS;
D O I：
10.1016/j.chemosphere.2016.12.127
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
To investigate the serum concentrations of organochlorine pesticides (OCPs) in patients with polycystic ovary syndrome (PCOS), a total of 178 women were studied. The concentrations of hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethane (DDT) in serum were determined using Gas Chromatography Mass-Mass Spectrometer. No differences with statistical significance in the mean HCH, p,p'-DDD, p,p'-DDE concentrations were observed between the patients with PCOS and the control group. Serum p,p'-DDT (P = 0.016) and o,p'-DDT (P = 0.000) levels were significantly higher in patients with PCOS compared with the control group. The results of the association between OCPs levels and hormone levels indicated that o,p'-DDT may play a role in the pathogenesis of PCOS by affecting hormones levels. Further trials should be investigated with the findings in this study to obtain new pathogenesis of PCOS. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：595 / 600
页数：6
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