Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues

被引：30

作者：

Ouahrouch, Abdelaaziz ^{[1
,2
]}

Taourirte, Moha ^{[1
]}

Engels, Joachim W. ^{[3
]}

Benjelloun, Soumaya ^{[4
]}

Lazrek, Hassan B. ^{[2
]}

机构：

[1] FSTG, Lab Bioorgan & Macromol Chem, Dept Chem, Marrakech 40000, Morocco

[2] Fac Sci Semlalia, Dept Chem, Lab Biomol & Med Chem, Marrakech 40000, Morocco

[3] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60438 Frankfurt, Germany

[4] Pasteur Inst Morocco, Viral Hepatitis Lab, Casablanca 20001, Morocco

来源：

MOLECULES | 2014年 / 19卷 / 03期

关键词：

quinazoline ribonucleosides; 1,2,3-triazole-acyclonucleosides; Huisgen cycloaddition; quinazolinone alkylation; HCV; ALKYNE 1,3-DIPOLAR CYCLOADDITION; ASSISTED CLICK CHEMISTRY; HEPATITIS-C; QUINAZOLINE DERIVATIVES; TRIAZOLYL-NUCLEOSIDES; BIOLOGICAL EVALUATION; TERMINAL ALKYNES; O-ALKYLATION; IN-VITRO; INTERFERON;

D O I：

10.3390/molecules19033638

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.

引用

页码：3638 / 3653

页数：16

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