3D molecular models of whole HIV-1 virions generated with cellPACK

被引：37

作者：

Johnson, Graham T. ^{[1
,2
,3
]}

Goodsell, David S. ^{[3
]}

Autin, Ludovic ^{[3
]}

Forli, Stefano ^{[3
]}

Sanner, Michel F. ^{[3
]}

Olson, Arthur J. ^{[3
]}

机构：

[1] Univ Calif San Francisco, San Francisco, CA 94143 USA

[2] Calif Inst Quantitat Biosci QB3, San Francisco, CA 94158 USA

[3] Scripps Res Inst, La Jolla, CA 92037 USA

来源：

FARADAY DISCUSSIONS | 2014年 / 169卷

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; CRYOELECTRON MICROSCOPY; STRUCTURAL BASIS; PLASMA-MEMBRANE; AIDS VIRUS; P2; DOMAIN; GAG; PROTEIN; ARCHITECTURE; TRAFFICKING;

D O I：

10.1039/c4fd00017j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

As knowledge of individual biological processes grows, it becomes increasingly useful to frame new findings within their larger biological contexts in order to generate new systems-scale hypotheses. This report highlights two major iterations of a whole virus model of HIV-1, generated with the cellPACK software. cellPACK integrates structural and systems biology data with packing algorithms to assemble comprehensive 3D models of cell-scale structures in molecular detail. This report describes the biological data, modeling parameters and cellPACK methods used to specify and construct editable models for HIV-1. Anticipating that cellPACK interfaces under development will enable researchers from diverse backgrounds to critique and improve the biological models, we discuss how cellPACK can be used as a framework to unify different types of data across all scales of biology.

引用

页码：23 / 44

页数：22

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