Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy

被引：52
作者：
Elahy, Mina [1 ]
Baindur-Hudson, Swati [1 ]
Cruzat, Vinicius F. [2 ,3 ]
Newsholme, Philip [2 ,3 ]
Dass, Crispin R. [3 ,4 ]
机构：
[1] Victoria Univ, Coll Hlth & Biomed, St Albans, Vic 3021, Australia
[2] Curtin Univ, Sch Biomed Sci, Perth, WA 6102, Australia
[3] Curtin Univ, Biosci Res Precinct, Perth, WA 6102, Australia
[4] Curtin Univ, Sch Pharm, Perth, WA 6102, Australia
来源：
JOURNAL OF ENDOCRINOLOGY | 2014年 / 222卷 / 03期
关键词：
PEDF; diabetes; oxidative stress; pericyte; signal transduction; redox balance; EPITHELIUM-DERIVED-FACTOR; GLYCATION END-PRODUCTS; ENDOTHELIAL-GROWTH-FACTOR; CEREBELLAR GRANULE CELLS; CULTURED RETINAL PERICYTES; ORTHOTOPIC OSTEOSARCOMA GROWTH; PPAR-GAMMA ACTIVATION; KAPPA-B ACTIVATION; PIGMENT-EPITHELIUM; OXIDATIVE STRESS;
D O I：
10.1530/JOE-14-0065
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.
引用
收藏
页码：R129 / R139
页数：11
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