PTEN, Stem Cells, and Cancer Stem Cells

被引：116

作者：

Hill, Reginald ^{[1
]}

Wu, Hong ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2009年 / 284卷 / 18期

基金：

美国国家卫生研究院;

关键词：

IN-VIVO; CONDITIONAL LOSS; PROSTATE-CANCER; SELF-RENEWAL; LEUKEMIA; TUMORIGENESIS; LEADS; RESISTANCE; DELETION; NOTCH1;

D O I：

10.1074/jbc.R800071200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Like normal stem cells, "cancer stem cells" have the capacity for indefinite proliferation and generation of new cancerous tissues through self-renewal and differentiation. Among the major intracellular signaling pathways, WNT, SHH, and NOTCH are known to be important in regulating normal stem cell activities, and their alterations are associated with tumorigenesis. It has become clear recently that PTEN (phosphatase and tensin homologue) is also critical for stem cell maintenance and that PTEN loss can cause the development of cancer stem cells and ultimately tumorigenesis.

引用

页码：11755 / 11759

页数：5

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