Intravesicular cidofovir for BK hemorrhagic cystitis in pediatric patients after hematopoietic stem cell transplant

被引：12
作者：
Foster, Jennifer H. [1 ,3 ]
Cheng, W. Susan [2 ]
Ngoc-Yen Nguyen [3 ]
Krance, Robert [1 ,3 ]
Martinez, Caridad [1 ,3 ]
机构：
[1] Baylor Coll Med, Houston, TX 77030 USA
[2] Benedictine Univ, Lisle, IL USA
[3] Texas Childrens Hosp, Houston, TX 77030 USA
来源：
PEDIATRIC TRANSPLANTATION | 2018年 / 22卷 / 03期
关键词：
BK virus hemorrhagic cystitis; hematopoietic stem cell transplantation; intravesicular cidofovir; BONE-MARROW-TRANSPLANTATION; POLYOMAVIRUS BK; RISK-FACTORS; VIRUS; CIPROFLOXACIN; RECIPIENTS; CHILDREN; LOAD;
D O I：
10.1111/petr.13141
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
BK virus hemorrhagic cystitis is a complication of HCST. Response to IV cidofovir is unpredictable, and treatment carries risk of toxicity. We report the largest series of pediatric patients with BKHC after HSCT successfully treated with intravesicular cidofovir. There was no significant decrease in urine or plasma BK PCR. There was significant decrease in pain score on days 3 and 7, with associated decrease in morphine use. No patients experienced toxicities associated with IV cidofovir. Intravesicular cidofovir appears to be safe and effective for symptomatic treatment of BKHC in pediatric patients after HSCT.
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页数：4
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