Intravesicular cidofovir for BK hemorrhagic cystitis in pediatric patients after hematopoietic stem cell transplant

被引：12
作者：
Foster, Jennifer H. [1 ,3 ]
Cheng, W. Susan [2 ]
Ngoc-Yen Nguyen [3 ]
Krance, Robert [1 ,3 ]
Martinez, Caridad [1 ,3 ]
机构：
[1] Baylor Coll Med, Houston, TX 77030 USA
[2] Benedictine Univ, Lisle, IL USA
[3] Texas Childrens Hosp, Houston, TX 77030 USA
来源：
PEDIATRIC TRANSPLANTATION | 2018年 / 22卷 / 03期
关键词：
BK virus hemorrhagic cystitis; hematopoietic stem cell transplantation; intravesicular cidofovir; BONE-MARROW-TRANSPLANTATION; POLYOMAVIRUS BK; RISK-FACTORS; VIRUS; CIPROFLOXACIN; RECIPIENTS; CHILDREN; LOAD;
D O I：
10.1111/petr.13141
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
BK virus hemorrhagic cystitis is a complication of HCST. Response to IV cidofovir is unpredictable, and treatment carries risk of toxicity. We report the largest series of pediatric patients with BKHC after HSCT successfully treated with intravesicular cidofovir. There was no significant decrease in urine or plasma BK PCR. There was significant decrease in pain score on days 3 and 7, with associated decrease in morphine use. No patients experienced toxicities associated with IV cidofovir. Intravesicular cidofovir appears to be safe and effective for symptomatic treatment of BKHC in pediatric patients after HSCT.
引用
收藏
页数：4
相关论文
共 19 条
[1]   Prevalence and stability of antibodies to the BK and JC polyomaviruses: a long-term longitudinal study of Australians [J].
Antonsson, Annika ;
Green, Adele C. ;
Mallitt, Kylie-Ann ;
O'Rourke, Peter K. ;
Pawlita, Michael ;
Waterboer, Tim ;
Neale, Rachel E. .
JOURNAL OF GENERAL VIROLOGY, 2010, 91 :1849-1853
[2]   Cidofovir bladder instillation for the treatment of BK hemorrhagic cystitis after allogeneic stem cell transplantation [J].
Bridges, Benjamin ;
Donegan, Sarah ;
Badros, Ashraf .
AMERICAN JOURNAL OF HEMATOLOGY, 2006, 81 (07) :535-537
[3]   Incidence and treatment of hemorrhagic cystitis in children given hematopoietic stem cell transplantation: a survey from the Italian association of pediatric hematology oncology-bone marrow transplantation group [J].
Cesaro, S ;
Brugiolo, A ;
Faraci, M ;
Uderzo, C ;
Rondelli, R ;
Favre, C ;
Zecca, M ;
Garetto, G ;
Dini, G ;
Pillon, M ;
Messina, C ;
Zanesco, L ;
Pession, A ;
Locatelli, F .
BONE MARROW TRANSPLANTATION, 2003, 32 (09) :925-931
[4]   Cidofovir for BK Virus-Associated Hemorrhagic Cystitis: A Retrospective Study [J].
Cesaro, Simone ;
Hirsch, Hans H. ;
Faraci, Maura ;
Owoc-Lempach, Joanna ;
Beltrame, Angela ;
Tendas, Andrea ;
Baltadakis, Ioannis ;
Dalle, Jean-Hughes ;
Koc, Yener ;
Toporski, Jacek ;
Styczynski, Jan ;
Yesilipek, M. Akif ;
Heinz, Werner ;
Caniglia, Maurizio ;
Rascon, Jelena ;
Fauser, Axel A. ;
Michallet, Mauricette ;
Lopez-Corral, Lucia ;
Neuburger, Stefan ;
Tridello, Gloria ;
Einsele, Herman .
CLINICAL INFECTIOUS DISEASES, 2009, 49 (02) :233-240
[5]   Decreased Viral Load and Symptoms of Polyomavirus-Associated Chronic Interstitial Cystitis after Intravesical Cidofovir Treatment [J].
Eisen, Damon P. ;
Fraser, Ian R. ;
Sung, Linda M. ;
Finlay, Moira ;
Bowden, Scott ;
O'Connell, Helen .
CLINICAL INFECTIOUS DISEASES, 2009, 48 (09) :E86-E88
[6]   Low-dose cidofovir in the treatment of symptomatic BK virus infection in patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective analysis of an algorithmic approach [J].
Ganguly, N. ;
Clough, L. A. ;
DuBois, L. K. ;
Mcguirk, J. P. ;
Abhyankar, S. ;
Aljitawi, O. S. ;
O'Neal, N. ;
Divine, C. L. ;
Ganguly, S. .
TRANSPLANT INFECTIOUS DISEASE, 2010, 12 (05) :406-411
[7]   Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir [J].
Held, TK ;
Biel, SS ;
Nitsche, A ;
Kurth, A ;
Chen, S ;
Gelderblom, HR ;
Siegert, W .
BONE MARROW TRANSPLANTATION, 2000, 26 (03) :347-350
[8]   BK virus: Opportunity makes a pathogen [J].
Hirsch, HH .
CLINICAL INFECTIOUS DISEASES, 2005, 41 (03) :354-360
[9]   Polyomavirus BK [J].
Hirsch, HH ;
Steiger, J .
LANCET INFECTIOUS DISEASES, 2003, 3 (10) :611-623
[10]   BK virus-associated fatal renal failure following late-onset hemorrhagic cystitis in an unrelated bone marrow transplantation [J].
Iwamoto, S ;
Azuma, E ;
Hori, H ;
Hirayama, M ;
Kobayashi, M ;
Komada, Y ;
Nishimori, H ;
Miyahara, M ;
Nishide, Y .
PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2002, 19 (04) :255-261
12