Epithelial-mesenchymal Transition and Cancer Stem Cells in Endometrial Cancer

被引：0

作者：

Supernat, Anna ^{[1
,2
]}

Lapinska-Szumczyk, Sylwia ^{[3
]}

Majewska, Hanna ^{[4
]}

Gulczynski, Jacek ^{[5
]}

Biernat, Wojciech ^{[4
]}

Wydra, Dariusz ^{[3
]}

Zaczek, Anna J. ^{[1
,2
]}

机构：

[1] Univ Gdansk, Intercollegiate Fac Biotechnol, Dept Med Biotechnol, PL-80211 Gdansk, Poland

[2] Med Univ Gdansk, Gdansk, Poland

[3] Med Univ Gdansk, Dept Gynaecol Gynaecol Oncol & Gynaecol Endocrino, Gdansk, Poland

[4] Med Univ Gdansk, Dept Pathomorphol, Gdansk, Poland

[5] Med Univ Gdansk, Dept Pathol & Neuropathol, Gdansk, Poland

来源：

ANTICANCER RESEARCH | 2013年 / 33卷 / 12期

关键词：

Epithelial-mesenchymal transition; cancer stem cells; molecular markers; quantitative PCR; endometrial cancer; COLORECTAL-CANCER; E-CADHERIN; BREAST; SNAIL; EXPRESSION; CD133; PHENOTYPE; CARCINOMA; IDENTIFICATION; INVASION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) are presumed to be key conditions for malignancy. Data concerning their role in endometrial cancer (EC) are scarce. We aimed to investigate the possible link between EMT and CSCs markers in EC samples. Materials and Methods: The study encompassed 156 primary tumour samples. Using RT-qPCR, we analyzed the expression of EMT-related genes, SNAIL and SLUG, and the CSCs marker CD133. Results: SNAIL and SLUG correlated with each other (R=0.33; p=0.00003). All the studied genes were expressed in both normal and malignant endometrial tissue. Decreased SNAIL expression was found to correlate with post-menopausal status (p=0.002). Decreased SLUG expression was associated with shorter overall survival (p=0.01). Conclusion: SLUG expression could serve as a prognostic factor in EC. No correlation between the expression of EMT and CSCs markers was found, suggesting there to be no association between the EMT and CSC phenotype in endometrial cancer.

引用

页码：5461 / 5469

页数：9

共 61 条

[1] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[2]

Alamgeer M, 2013, THORAX

[3] Transcription factors associated with epithelial-mesenchymal transition and cancer stem cells in the tumor centre and margin of invasive breast cancer [J].

Alkatout, Ibrahim ;

Wiedermann, Meike ;

Bauer, Maret ;

Wenners, Antonia ;

Jonat, Walter ;

Klapper, Wolfram .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2013, 94 (01) :168-173

[4] Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies [J].

Barba, C ;

Cavalli-Sforza, T ;

Cutter, J ;

Darnton-Hill, I ;

Deurenberg, P ;

Deurenberg-Yap, M ;

Gill, T ;

James, P ;

Ko, G ;

Miu, AH ;

Kosulwat, V ;

Kumanyika, S ;

Kurpad, A ;

Mascie-Taylor, N ;

Moon, HK ;

Nishida, C ;

Noor, MI ;

Reddy, KS ;

Rush, E ;

Schultz, JT ;

Seidell, J ;

Stevens, J ;

Swinburn, B ;

Tan, K ;

Weisell, R ;

Wu, ZS ;

Yajnik, CS ;

Yoshiike, N ;

Zimmet, P .

LANCET, 2004, 363 (9403) :157-163

[5] Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative [J].

Biddle, Adrian ;

Liang, Xiao ;

Gammon, Luke ;

Fazil, Bilal ;

Harper, Lisa J. ;

Emich, Helena ;

Costea, Daniela Elena ;

Mackenzie, Ian C. .

CANCER RESEARCH, 2011, 71 (15) :5317-5326

[6] The e-cadherin repressor snail plays a role in tumor progression of Endometrioid adenocarcinomas [J].

Blechschmidt, Kareen ;

Kremmer, Elisabeth ;

Hollweck, Regina ;

Mylonas, Ioannis ;

Hoefler, Heinz ;

Kremer, Marcus ;

Becker, Karl-Friedrich .

DIAGNOSTIC MOLECULAR PATHOLOGY, 2007, 16 (04) :222-228

[7] The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments [J].

Bustin, Stephen A. ;

Benes, Vladimir ;

Garson, Jeremy A. ;

Hellemans, Jan ;

Huggett, Jim ;

Kubista, Mikael ;

Mueller, Reinhold ;

Nolan, Tania ;

Pfaffl, Michael W. ;

Shipley, Gregory L. ;

Vandesompele, Jo ;

Wittwer, Carl T. .

CLINICAL CHEMISTRY, 2009, 55 (04) :611-622

[8]

Cai Cheng, 2013, Zhonghua Wei Chang Wai Ke Za Zhi, V16, P662

[9]

Chen C, 2012, CANC LETT

[10] Epithelial-mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer [J].

Chu, Pen-Yuan ;

Hu, Fang-Wei ;

Yu, Cheng-Chia ;

Tsai, Lo-Lin ;

Yu, Chuan-Hang ;

Wu, Buor-Chang ;

Chen, Yi-Wei ;

Huang, Pin-I ;

Lo, Wen-Liang .

ORAL ONCOLOGY, 2013, 49 (01) :34-41

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