Nonmetastatic Castration-resistant Prostate Cancer: A Modern Perspective

被引：6
作者：
Cancian, Madeline [1 ]
Renzulli, Joseph F., II
机构：
[1] Brown Univ, Warren Alpert Med Sch, Dept Urol, 2 Dudley St,Suite 174, Providence, RI 02903 USA
来源：
UROLOGY | 2018年 / 116卷
关键词：
ANDROGEN-RECEPTOR; CHOLINE-PET/CT; ANTIANDROGEN; ANTIGEN; TRIAL; VARIANTS; TIME; MEN;
D O I：
10.1016/j.urology.2018.01.010
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Nonmetastatic castration-resistant prostate cancer (nmCRPC) presents a challenge to urologists as currently there are no Food and Drug Administration-approved therapies. However, there are new imaging modalities, including fluciclovine positron emission tomography-computed tomography and Ga-PSMA (prostate specific membrane antigent) positron emission tomography-computed tomography, which are improving accuracy of diagnosis. With improved imaging, we are better able to target therapy. Today there are 3 ongoing clinical trials studying second-generation antiandrogens in nmCRPC, which hold the promise of a new treatment paradigm. In this article, we will review the new imaging techniques and the rationale behind novel treatment modalities in nmCRPC. (C) 2018 Elsevier Inc.
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页码：13 / 16
页数：4
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