Magnesium and Calcium in Exhaled Breath Condensate of Children with Asthma and Gastroesophageal Reflux Disease

被引：10

作者：

Dodig, Slavica ^{[1
]}

Vlasic, Zeljka ^{[1
]}

Cepelak, Ivana ^{[2
]}

Topic, Renata Zrinski ^{[1
]}

Turkalj, Mirjana ^{[1
]}

Nogalo, Boro ^{[1
]}

机构：

[1] Srebrnjak Childrens Hosp, Reference Ctr Clin Pediat Allergol, Minist Hlth & Social Welf, HR-10000 Zagreb, Croatia

[2] Univ Zagreb, Fac Pharm & Biochem, Dept Med Biochem & Hematol, Zagreb 41000, Croatia

来源：

JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2009年 / 23卷 / 01期

关键词：

asthma; calcium; exhaled breath condensate; gastroesophageal reflux disease; magnesium; OBSTRUCTIVE PULMONARY-DISEASE; BRONCHIAL SMOOTH-MUSCLE; OXIDATIVE STRESS; LUNG-DISEASE; INTRAVENOUS MAGNESIUM; AIRWAY INFLAMMATION; CYSTIC-FIBROSIS; 8-ISOPROSTANE; PH; DEFICIENCY;

D O I：

10.1002/jcla.20286

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background. Magnesium and calcium physiologic functions are closely related. Magnesium is primarily an intracellular cation, the action of which also involves maintenance of cellular ionic balance, while influencing calcium homeostasis by blocking calcium channels. The aim of this study was to compare the concentrations of magnesium and calcium in exhaled breath condensate (EBC) of children with asthma and gastroesophageal reflux disease (GERD). Subjects and methods: EBC was collected from 66 children aged 7-14 years (23 children with acute asthma, 17 children with GERD, and 26 healthy children). Determination of magnesium and calcium concentrations was preceded by optimization and validation for low concentrations. Results: No difference was recorded for either magnesium or calcium concentration between study groups. However, the magnesium to calcium ratio was statistically significantly lower in both GERD and asthma children as compared with control group. Conclusion: Study results showed the magnesium to calcium ratio to be a statistically significantly better indicator of certain pathologic changes than absolute concentration of either ion. J. Clin. Lab. Anal. 23: 34-39, 2009. (C) 2009 Wiley-Liss, Inc.

引用

页码：34 / 39

页数：6

共 48 条

[1]

[Anonymous], GLOBAL STRATEGY ASTH

[2] Reproducibility of exhaled breath condensate pH in chronic obstructive pulmonary disease [J].

Borrill, Z ;

Starkey, C ;

Vestbo, J ;

Singh, D .

EUROPEAN RESPIRATORY JOURNAL, 2005, 25 (02) :269-274

[3] Asthma - From bronchoconstriction to airways inflammation and remodeling [J].

Bousquet, J ;

Jeffery, PK ;

Busse, WW ;

Johnson, M ;

Vignola, AM .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (05) :1720-1745

[4] DIETARY MAGNESIUM, LUNG-FUNCTION, WHEEZING, AND AIRWAY HYPERREACTIVITY IN A RANDOM ADULT-POPULATION SAMPLE [J].

BRITTON, J ;

PAVORD, I ;

RICHARDS, K ;

WISNIEWSKI, A ;

KNOX, A ;

LEWIS, S ;

TATTERSFIELD, A ;

WEISS, S .

LANCET, 1994, 344 (8919) :357-362

[5] Increased phagocytosis and production of reactive oxygen species by neutrophils during magnesium deficiency in rats and inhibition by high magnesium concentration [J].

Bussière, FI ;

Gueux, E ;

Rock, E ;

Girardeau, JP ;

Tridon, A ;

Mazur, A ;

Rayssiguier, Y .

BRITISH JOURNAL OF NUTRITION, 2002, 87 (02) :107-113

[6] Magnesium attenuates the neutrophil respiratory burst in adult asthmatic patients [J].

Cairns, CB ;

Kraft, M .

ACADEMIC EMERGENCY MEDICINE, 1996, 3 (12) :1093-1097

[7]

Carpagnano GE, 2007, ONCOL RES, V16, P375

[8] Exhaled breath condensate: a new method for lung disease diagnosis [J].

Cepelak, Ivana ;

Dodig, Slavica .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2007, 45 (08) :945-952

[9] Intravenous magnesium therapy for moderate to severe pediatric asthma: Results of a randomized, placebo-controlled trial [J].

Ciarallo, L ;

Sauer, AH ;

Shannon, MW .

JOURNAL OF PEDIATRICS, 1996, 129 (06) :809-814

[10] Acetylcholine-induced asynchronous calcium waves in intact human bronchial muscle bundle [J].

Dai, Jiazhen M. ;

Kuo, Kuo-Hsing ;

Leo, Joyce M. ;

Pare, Peter D. ;

Van Breemen, Cornelis ;

Lee, Cheng-Han .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2007, 36 (05) :600-608

← 1 2 3 4 5 →