Less white matter concentration in autism: 2D voxel-based morphometry

被引:109
作者
Chung, MK
Dalton, KM
Alexander, AL
Davidson, RJ
机构
[1] Univ Wisconsin, Dept Stat, Madison, WI 53706 USA
[2] Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI 53706 USA
[3] Univ Wisconsin, Keck Lab Funct Brain Imaging & Behav, Madison, WI 53706 USA
[4] Univ Wisconsin, Dept Med Phys, Madison, WI 53706 USA
[5] Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA
[6] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA
关键词
autism; voxel; morphometry;
D O I
10.1016/j.neuroimage.2004.04.037
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Autism is a neurodevelopmental disorder affecting behavioral and social cognition, but there is little understanding about the link between the functional deficit and its underlying neuroanatomy. We applied a 2D version of voxel-based morphometry (VBM) in differentiating the white matter concentration of the corpus callosum for the group of 16 high functioning autistic and 12 normal subjects. Using the white matter density as an index for neural connectivity, autism is shown to exhibit less white matter concentration in the region of the genu, rostrum, and splenium removing the effect of age based on the general linear model (GLM) framework. Further, it is shown that the less white matter concentration in the corpus callosum in autism is due to hypoplasia rather than atrophy. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:242 / 251
页数:10
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