Cobalt-Catalyzed Arylzincation of Alkynes

被引：53

作者：

Murakami, Kei ^{[1
]}

Yorimitsu, Hideki ^{[1
]}

Oshima, Koichiro ^{[1
]}

机构：

[1] Kyoto Univ, Dept Chem Mat, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 11期

关键词：

CARBON BOND-FORMATION; STEREOSELECTIVE-SYNTHESIS; TETRASUBSTITUTED ALKENES; SYNTHETIC REACTIONS; SELECTIVE SYNTHESIS; COUPLING REACTIONS; REAGENTS; CARBOZINCATION; EFFICIENT; ARYLMAGNESIATION;

D O I：

10.1021/ol900883j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cobalt(II) bromide catalyzes arylzincation of alkynes with arylzinc iodide center dot lithium chloride complexes in acetonitrile. The scope of the arylzincation is wide enough to use unfunctionalized alkynes, such as 6-dodecyne, as well as arylacetylenes. The inherent functional group compatibility of arylzinc reagents allows preparation of various functionalized styrene derivatives. The reaction is applicable to the efficient and stereoselective synthesis of a synthetic estrogen and its derivative.

引用

页码：2373 / 2375

页数：3

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