Evidence Required to Demonstrate Clinical Utility of Pharmacogenetic Testing: The Debate Continues

被引:37
作者
Gillis, N. K. [1 ]
Innocenti, F. [1 ,2 ]
机构
[1] Univ N Carolina, Eshelman Sch Pharm, Ctr Pharmacogen & Individualized Therapy, Chapel Hill, NC 27514 USA
[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
关键词
D O I
10.1038/clpt.2014.185
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Pharmacogenetics is an area of research that has potential to greatly benefit patients. However, the routine use of diagnostic pharmacogenetic testing to inform treatment decisions is limited. Here we discuss the determination of clinical utility of pharmacogenetic testing and the level of evidence required to support translation into clinical practice.
引用
收藏
页码:655 / 657
页数:3
相关论文
共 10 条
[1]   Debating Clinical Utility [J].
Burke, W. ;
Laberge, A. -M. ;
Press, N. .
PUBLIC HEALTH GENOMICS, 2010, 13 (04) :215-223
[2]  
Centers for Disease Control and Prevention Office of Public Health Genomics, 2010, GEN TEST ACCE MOD PR
[3]   Clinical Implementation of Germ Line Cancer Pharmacogenetic Variants During the Next-Generation Sequencing Era [J].
Gillis, N. K. ;
Patel, J. N. ;
Innocenti, F. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2014, 95 (03) :269-280
[4]   Charting a course for genomic medicine from base pairs to bedside [J].
Green, Eric D. ;
Guyer, Mark S. .
NATURE, 2011, 470 (7333) :204-213
[5]  
Holtzman N A, 1999, J Child Fam Nurs, V2, P388
[6]  
Inst Med, 2010, EVALUATION OF BIOMARKERS AND SURROGATE ENDPOINTS IN CHRONIC DISEASE, P1
[7]   Medicare's Enduring Struggle to Define "Reasonable and Necessary" Care [J].
Neumann, Peter J. ;
Chambers, James D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (19) :1775-1777
[8]   Bring on the biomarkers [J].
Poste, George .
NATURE, 2011, 469 (7329) :156-157
[9]  
US National Library of Medicine National Institutes of Health, 2014, GEN HOM REF HDB CAN
[10]  
World Health Organization, 2014, QUAL SAF GEN TEST EM