Type I lnterferons Modulate CD8+ T Cell Immunity to mRNA Vaccines

被引：79
作者：
De Beuckelaer, Ans [1 ]
Grooten, Johan [1 ]
De Koker, Stefaan [1 ,2 ]
机构：
[1] Univ Ghent, Dept Biomed Mol Biol, Lab Mol Immunol, Ghent, Belgium
[2] Univ Ghent, Dept Biochem, Cytokine Receptor Lab, Ghent, Belgium
来源：
TRENDS IN MOLECULAR MEDICINE | 2017年 / 23卷 / 03期
关键词：
PERSISTENT LCMV INFECTION; TOLL-LIKE RECEPTORS; DENDRITIC CELLS; INTERFERON-ALPHA; STRANDED-RNA; RIG-I; EXPRESSION KINETICS; ADAPTIVE IMMUNITY; STRUCTURAL BASIS; BACTERIAL-DNA;
D O I：
10.1016/j.molmed.2017.01.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
mRNA vaccines have emerged as potent tools to elicit antitumor T cell immunity. They are characterized by a strong induction of type I interferons (IFNs), potent inflammatory cytokines affecting T cell differentiation and survival. Recent reports have attributed opposing roles for type I IFNs in modulating CD8(+) T cell immunity to mRNA vaccines, from profoundly stimulatory to strongly inhibitory. The mechanisms behind this duality are unclear. Disentangling the factors governing the beneficial or detrimental impact of type I IFNs on CD8(+) T cell responses is vital to the design of mRNA vaccines of increased potency. In light of recent advancements regarding the complex role of type I IFNs in regulating CD8(+) T cell immunity to infectious diseases, we posit that the dual outcome of type I IFNs on CD8(+) T cell responses to mRNA vaccination is determined by the timing and intensity of type I IFN induction relative to T cell receptor (TCR) activation.
引用
收藏
页码：216 / 226
页数：11
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