Vesicular self-assembly of a natural triterpenoid arjunolic acid in aqueous medium: study of entrapment properties and in situ generation of gel-gold nanoparticle hybrid material

被引：48
作者：
Bag, Braja Gopal [1 ]
Majumdar, Rakhi [1 ]
机构：
[1] Vidyasagar Univ, Dept Chem & Chem Technol, Midnapore 72102, W Bengal, India
来源：
RSC ADVANCES | 2014年 / 4卷 / 95期
关键词：
DRUG-DELIVERY; OXIDOSQUALENE CYCLASE; ENZYME MECHANISMS; SOFT MATERIALS; VESICLES; AMPHIPHILES; CYCLIZATION; HYDROGELS; SQUALENE; ORGANOGELS;
D O I：
10.1039/c4ra08710k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A natural pentacyclic triterpenoid arjunolic acid self-assembled hierarchically in aqueous solvents yielding vesicular structures of nano to micrometer diameters affording gels. This self-assembly has been utilized for the entrapment and controlled release of anticancer drugs such as doxorubicin at physiological pH. A gel-gold nanoparticle hybrid material has also been prepared by in situ generated gold nanoparticles at room temperature.
引用
收藏
页码：53327 / 53334
页数：8
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