Complete nucleotide sequences and genome organization of four chimpanzee adenoviruses

被引：40

作者：

Roy, S

Gao, GP

Clawson, DS

Vandenberghe, LH

Farina, SF

Wilson, JM

机构：

[1] Univ Penn, Sch Med, Dept Med, Div Med Genet,Gene Therapy Program, Philadelphia, PA 19104 USA

[2] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

[3] Katholieke Univ Leuven, Rega Inst Med Res, Gene Therapy Program, B-3000 Louvain, Belgium

来源：

VIROLOGY | 2004年 / 324卷 / 02期

关键词：

nucleotide sequence; genome organization; chimpanzee;

D O I：

10.1016/j.virol.2004.03.047

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The complete nucleotide sequences for four adenoviruses-Simian Adenoviruses 21, 22, 23, and 24, originally isolated from chimpanzees, were determined. The genome organization of the chimpanzee adenoviruses was found to be similar to that of other adenoviruses. The viral gene products of the adenoviruses Simian Adenoviruses 22, 23, and 24 are very closely related to those of the (previously sequenced) chimpanzee adenovirus Simian Adenovirus 25. Simian Adenovirus 21 is most similar to human subgroup B adenoviruses HAdV-3, HAdV-7, and HAdV-35. Analysis of the capsid proteins hexon and fiber of the chimpanzee adenoviruses also supports the placement of Simian Adenovirus 21 in subgroup B and Simian Adenoviruses 22, 23, and 24 in subgroup E. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：361 / 372

页数：12

共 40 条

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