Effect of substituents on DNA-binding behaviors of ruthenium(II) complexes: [Ru(dmb)2(dtmi)]2+and [Ru(dmb)2(dtni)]2+

被引：9

作者：

Liu, Yi ^{[1
]}

Liu, Yun-Jun ^{[1
]}

Yao, Jun-Hua ^{[2
]}

Mei, Wen-Jie ^{[1
]}

Wu, Fu-Hai ^{[3
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Instrumentat Anal & Res Ctr, Guangzhou 510275, Guangdong, Peoples R China

[3] Guangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2009年 / 62卷 / 10期

关键词：

Ru(II) complex; DNA; Thermal denaturation; DEOXYRIBONUCLEIC-ACID; PHOTOCLEAVAGE; LIGANDS; TRIS(PHENANTHROLINE)RUTHENIUM(II); 1,10-PHENANTHROLINE; SPECTROSCOPY; MODE;

D O I：

10.1080/00958970802649984

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two Ru(II) complexes [Ru(dmb)2(dtmi)](ClO4)2 (1) (dmb = 4, 4'-dimethyl-2, 2'-bipyridine, dtmi = 3-(pyrazin-2-yl)-as-triazino[5, 6-f]-5-methoxylisatin) and [Ru(dmb)2(dtni)](ClO4)2 (2) (dtni = 3-(pyrazin-2-yl)-as-triazino[5, 6-f]-5-nitroisatin) have been synthesized and characterized by elemental analysis, ES-MS, and 1H NMR. DNA-binding behaviors of these complexes have been investigated by spectroscopic titration, viscosity measurements, and thermal denaturation. The results indicate that the two complexes interact with calf thymus DNA by intercalation.

引用

页码：1701 / 1708

页数：8

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