Graphene: an emerging material for biological tissue engineering

被引:78
作者
Lee, Sang Kyu [1 ]
Kim, Hyun [1 ]
Shim, Bong Sup [1 ]
机构
[1] Inha Univ, Dept Chem Engn, Inchon 402751, South Korea
关键词
graphene; graphene oxide; carbon nanomaterials; tissue engineering; cell scaffolds; drug delivery; neural interface; biomaterials; biocompatibility; CONDUCTING POLYMERS; DRUG-DELIVERY; STEM-CELLS; BIONIC INTERFACE; OXIDE; DIFFERENTIATION; CULTURE; BIOCOMPATIBILITY; COMPOSITES; CHALLENGES;
D O I
10.5714/CL.2013.14.2.063
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Graphene, a carbon crystal sheet of molecular thickness, shows diverse and exceptional properties ranging from electrical and thermal conductivities, to optical and mechanical qualities. Thus, its potential applications include not only physicochemical materials but also extends to biological uses. Here, we review recent experimental studies about graphene for such bioapplications. As a prerequisite to the search to determine the potential of graphene for bioapplications, the essential qualities of graphene that support biocompatibility, were briefly summarized. Then, direct examples of tissue regeneration and tissue engineering utilizing graphenes, were discussed, including uses for cell scaffolds, cell modulating interfaces, drug delivery, and neural interfaces.
引用
收藏
页码:63 / 75
页数:13
相关论文
共 55 条
[1]   Drug delivery systems: Entering the mainstream [J].
Allen, TM ;
Cullis, PR .
SCIENCE, 2004, 303 (5665) :1818-1822
[2]   Chitosan-Functionalized Graphene Oxide as a Nanocarrier for Drug and Gene Delivery [J].
Bao, Hongqian ;
Pan, Yongzheng ;
Ping, Yuan ;
Sahoo, Nanda Gopal ;
Wu, Tongfei ;
Li, Lin ;
Li, Jun ;
Gan, Leong Huat .
SMALL, 2011, 7 (11) :1569-1578
[3]  
Bendali A, 2013, ADV HEALTHC IN PRESS
[4]   In vitro toxicity evaluation of graphene oxide on A549 cells [J].
Chang, Yanli ;
Yang, Sheng-Tao ;
Liu, Jia-Hui ;
Dong, Erya ;
Wang, Yanwen ;
Cao, Aoneng ;
Liu, Yuanfang ;
Wang, Haifang .
TOXICOLOGY LETTERS, 2011, 200 (03) :201-210
[5]  
Chen CH, 2013, NANOMEDICIN IN PRESS
[6]   A graphene-based platform for induced pluripotent stem cells culture and differentiation [J].
Chen, G. -Y. ;
Pang, D. W. -P. ;
Hwang, S. -M. ;
Tuan, H. -Y. ;
Hu, Y. -C. .
BIOMATERIALS, 2012, 33 (02) :418-427
[7]   Neural stimulation and recording electrodes [J].
Cogan, Stuart F. .
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2008, 10 :275-309
[8]   Graphene and Nanowire Transistors for Cellular Interfaces and Electrical Recording [J].
Cohen-Karni, Tzahi ;
Qing, Quan ;
Li, Qiang ;
Fang, Ying ;
Lieber, Charles M. .
NANO LETTERS, 2010, 10 (03) :1098-1102
[9]   Controlled release of drug from folate-decorated and graphene mediated drug delivery system: Synthesis, loading efficiency, and drug release response [J].
Depan, D. ;
Shah, J. ;
Misra, R. D. K. .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2011, 31 (07) :1305-1312
[10]   The chemistry of graphene oxide [J].
Dreyer, Daniel R. ;
Park, Sungjin ;
Bielawski, Christopher W. ;
Ruoff, Rodney S. .
CHEMICAL SOCIETY REVIEWS, 2010, 39 (01) :228-240