Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms

被引:40
作者
Frame, Fiona M. [1 ]
Maitland, Norman J. [1 ]
机构
[1] Univ York, Dept Biol, YCR Canc Res Unit, Heslington YO10 5DD, N Yorkshire, England
来源
HUMAN CELL TRANSFORMATION: ROLE OF STEM CELLS AND THE MICROENVIRONMENT | 2012年 / 720卷
关键词
HUMAN PROSTATE-CANCER; ACUTE MYELOID-LEUKEMIA; EPITHELIAL-MESENCHYMAL TRANSITION; INITIATING CELLS; SELF-RENEWAL; STEM/PROGENITOR CELLS; ABC TRANSPORTERS; GENE-EXPRESSION; DNA-DAMAGE; IDENTIFICATION;
D O I
10.1007/978-1-4614-0254-1_9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
There is now compelling evidence for tumour initiating or cancer stem cells (CSCs) in human cancers. The current evidence of this CSC hypothesis, the CSC phenotype and methods of identification, culture and in vitro modelling will be presented, with an emphasis on prostate cancer. Inherent in the CSC hypothesis is their dual role, as a tumour-initiating cell, and as a source of treatment-resistant cells; the mechanisms behind therapeutic resistance will be discussed. Such resistance is a consequence of the unique CSC phenotype, which differs from the differentiated progeny, which make up the bulk of a tumour. It seems that to target the whole tumour, employing traditional therapies to target bulk populations alongside targeted CSC-specific drugs, provides the best hope of lasting treatment or even cure.
引用
收藏
页码:105 / 118
页数:14
相关论文
共 131 条
[1]   Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes [J].
Aasen, Trond ;
Raya, Angel ;
Barrero, Maria J. ;
Garreta, Elena ;
Consiglio, Antonella ;
Gonzalez, Federico ;
Vassena, Rita ;
Bilic, Josipa ;
Pekarik, Vladimir ;
Tiscornia, Gustavo ;
Edel, Michael ;
Boue, Stephanie ;
Izpisua Belmonte, Juan Carlos .
NATURE BIOTECHNOLOGY, 2008, 26 (11) :1276-1284
[2]   Therapeutic implications of cancer stem cells [J].
Al-Hajj, M ;
Becker, MW ;
Wichal, M ;
Weissman, I ;
Clarke, MF .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2004, 14 (01) :43-47
[3]   Attributes of adult stem cells [J].
Alison, M. R. ;
Islam, S. .
JOURNAL OF PATHOLOGY, 2009, 217 (02) :144-160
[4]   Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].
Bao, Shideng ;
Wu, Qiulian ;
McLendon, Roger E. ;
Hao, Yueling ;
Shi, Qing ;
Hjelmeland, Anita B. ;
Dewhirst, Mark W. ;
Bigner, Darell D. ;
Rich, Jeremy N. .
NATURE, 2006, 444 (7120) :756-760
[5]   OPINION Is NF-κB a good target for cancer therapy? Hopes and pitfalls [J].
Baud, Veronique ;
Karin, Michael .
NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (01) :33-40
[6]   Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions [J].
Birnie, Richard ;
Bryce, Steven D. ;
Roome, Claire ;
Dussupt, Vincent ;
Droop, Alastair ;
Lang, Shona H. ;
Berry, Paul A. ;
Hyde, Catherine F. ;
Lewis, John L. ;
Stower, Michael J. ;
Maitland, Norman J. ;
Collins, Anne T. .
GENOME BIOLOGY, 2008, 9 (05)
[7]   Molecular Signatures of Prostate Stem Cells Reveal Novel Signaling Pathways and Provide Insights into Prostate Cancer [J].
Blum, Roy ;
Gupta, Rashmi ;
Burger, Patricia E. ;
Ontiveros, Christopher S. ;
Salm, Sarah N. ;
Xiong, Xiaozhong ;
Kamb, Alexander ;
Wesche, Holger ;
Marshall, Lisa ;
Cutler, Gene ;
Wang, Xiangyun ;
Zavadil, Jiri ;
Moscatelli, David ;
Wilson, E. Lynette .
PLOS ONE, 2009, 4 (05)
[8]   Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271 [J].
Boiko, Alexander D. ;
Razorenova, Olga V. ;
van de Rijn, Matt ;
Swetter, Susan M. ;
Johnson, Denise L. ;
Ly, Daphne P. ;
Butler, Paris D. ;
Yang, George P. ;
Joshua, Benzion ;
Kaplan, Michael J. ;
Longaker, Michael T. ;
Weissman, Irving L. .
NATURE, 2010, 466 (7302) :133-U155
[9]   Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].
Bonnet, D ;
Dick, JE .
NATURE MEDICINE, 1997, 3 (07) :730-737
[10]   Identification of a tumor-initiating stem cell population in human renal carcinomas [J].
Bussolati, Benedetta ;
Bruno, Stefania ;
Grange, Cristina ;
Ferrando, Ugo ;
Camussi, Giovanni .
FASEB JOURNAL, 2008, 22 (10) :3696-3705