Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges

被引：112
作者：
Aaby, Peter [1 ,2 ,3 ]
Kollmann, Tobias R. [4 ]
Benn, Christine Stabell [1 ,2 ,3 ]
机构：
[1] Indepth Network, Bandim Hlth Project, Bissau, Guinea Bissau
[2] Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, OPEN, Odense, Denmark
[3] Statens Serum Inst, Res Ctr Vitamins & Vaccines, Bandim Hlth Project, DK-2300 Copenhagen, Denmark
[4] Univ British Columbia, Child & Family Res Inst, Dept Pediat, Div Infect Dis, Vancouver, BC V5Z 1M9, Canada
来源：
NATURE IMMUNOLOGY | 2014年 / 15卷 / 10期
基金：
欧洲研究理事会;
关键词：
BACILLUS-CALMETTE-GUERIN; DIPHTHERIA-TETANUS-PERTUSSIS; RANDOMIZED CONTROLLED-TRIAL; BIRTH-WEIGHT CHILDREN; BCG VACCINATION; TUBERCULIN REACTION; FEMALE MORTALITY; MEASLES-VACCINE; GUINEA-BISSAU; RESPONSES;
D O I：
10.1038/ni.2961
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to its greatest benefit. The World Health Organization has identified investigations into the molecular basis of nonspecific vaccine effects as a research priority.
引用
收藏
页码：895 / 899
页数：5
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