Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges

被引：112
作者：
Aaby, Peter [1 ,2 ,3 ]
Kollmann, Tobias R. [4 ]
Benn, Christine Stabell [1 ,2 ,3 ]
机构：
[1] Indepth Network, Bandim Hlth Project, Bissau, Guinea Bissau
[2] Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, OPEN, Odense, Denmark
[3] Statens Serum Inst, Res Ctr Vitamins & Vaccines, Bandim Hlth Project, DK-2300 Copenhagen, Denmark
[4] Univ British Columbia, Child & Family Res Inst, Dept Pediat, Div Infect Dis, Vancouver, BC V5Z 1M9, Canada
来源：
NATURE IMMUNOLOGY | 2014年 / 15卷 / 10期
基金：
欧洲研究理事会;
关键词：
BACILLUS-CALMETTE-GUERIN; DIPHTHERIA-TETANUS-PERTUSSIS; RANDOMIZED CONTROLLED-TRIAL; BIRTH-WEIGHT CHILDREN; BCG VACCINATION; TUBERCULIN REACTION; FEMALE MORTALITY; MEASLES-VACCINE; GUINEA-BISSAU; RESPONSES;
D O I：
10.1038/ni.2961
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to its greatest benefit. The World Health Organization has identified investigations into the molecular basis of nonspecific vaccine effects as a research priority.
引用
收藏
页码：895 / 899
页数：5
相关论文
共 29 条
  • [1] Differences in female-male mortality after high-titre measles vaccine and association with subsequent vaccination with diphtheria-tetanus-pertussis and inactivated poliovirus: reanalysis of West African studies
    Aaby, P
    Jensen, H
    Samb, B
    Cisse, B
    Sodemann, M
    Jakobsen, M
    Poulsen, A
    Rodrigues, A
    Lisse, IM
    Simondon, F
    Whittle, H
    [J]. LANCET, 2003, 361 (9376) : 2183 - 2188
  • [2] Vaccinia scars associated with better survival for adults - An observational study from Guinea-Bissau
    Aaby, Peter
    Gustafson, Per
    Roth, Adam
    Rodrigues, Amabelia
    Fernandes, Manuel
    Sodemann, Morten
    Holmgren, Birgitta
    Benn, Christine Stabell
    Garly, May-Lill
    Lisse, Ida Maria
    Jensen, Henrik
    [J]. VACCINE, 2006, 24 (29-30) : 5718 - 5725
  • [3] The optimal age of measles immunisation in low-income countries: a secondary analysis of the assumptions underlying the current policy
    Aaby, Peter
    Martins, Cesario L.
    Garly, May-Lill
    Rodrigues, Amabelia
    Benn, Christine S.
    Whittle, Hilton
    [J]. BMJ OPEN, 2012, 2 (04):
  • [4] Testing the hypothesis that diphtheria-tetanus-pertussis vaccine has negative non-specific and sex-differential effects on child survival in high-mortality countries
    Aaby, Peter
    Benn, Christine
    Nielsen, Jens
    Lisse, Ida Maria
    Rodrigues, Amabelia
    Ravn, Henrik
    [J]. BMJ OPEN, 2012, 2 (03):
  • [5] Early diphtheria-tetanus-pertussis vaccination associated with higher female mortality and no difference in male mortality in a cohort of low birthweight children: an observational study within a randomised trial
    Aaby, Peter
    Ravn, Henrik
    Roth, Adam
    Rodrigues, Amabelia
    Lisse, Ida Maria
    Diness, Birgitte Rode
    Lausch, Karen Rokkedal
    Lund, Najaaraq
    Rasmussen, Julie
    Biering-Sorensen, Sofie
    Whittle, Hilton
    Benn, Christine Stabell
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD, 2012, 97 (08) : 685 - 691
  • [6] Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial
    Aaby, Peter
    Martins, Cesario L.
    Garly, May-Lill
    Bale, Carlito
    Andersen, Andreas
    Rodrigues, Amabelia
    Ravn, Henrik
    Lisse, Ida M.
    Benn, Christine S.
    Whittle, Hilton C.
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2010, 341 : 1262
  • [7] [Anonymous], 2014, SYSTEMATIC REV NONSP
  • [8] [Anonymous], 2014, Wkly Epidemiol Rec, V89, P221
  • [9] Vitamin A supplementation and BCG vaccination at birth in low birthweight neonates: two by two factorial randomised controlled trial
    Benn, Christine Stabell
    Fisker, Ane Baerent
    Napirna, Bitiguida Mutna
    Roth, Adam
    Diness, Birgitte Rode
    Lausch, Karen Rokkedal
    Ravn, Henrik
    Yazdanbakhsh, Maria
    Rodrigues, Amabelia
    Whittle, Hilton
    Aaby, Peter
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2010, 340 : 636
  • [10] Should infant girls receive micronutrient supplements
    Benn, Christine Stabell
    Lund, Sofia
    Fisker, Ane
    Jorgensen, Mathias Jul
    Aaby, Peter
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2009, 38 (02) : 586 - 590
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