Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges

被引：113

作者：

Aaby, Peter ^{[1
,2
,3
]}

Kollmann, Tobias R. ^{[4
]}

Benn, Christine Stabell ^{[1
,2
,3
]}

机构：

[1] Indepth Network, Bandim Hlth Project, Bissau, Guinea Bissau

[2] Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, OPEN, Odense, Denmark

[3] Statens Serum Inst, Res Ctr Vitamins & Vaccines, Bandim Hlth Project, DK-2300 Copenhagen, Denmark

[4] Univ British Columbia, Child & Family Res Inst, Dept Pediat, Div Infect Dis, Vancouver, BC V5Z 1M9, Canada

来源：

NATURE IMMUNOLOGY | 2014年 / 15卷 / 10期

基金：

欧洲研究理事会;

关键词：

BACILLUS-CALMETTE-GUERIN; DIPHTHERIA-TETANUS-PERTUSSIS; RANDOMIZED CONTROLLED-TRIAL; BIRTH-WEIGHT CHILDREN; BCG VACCINATION; TUBERCULIN REACTION; FEMALE MORTALITY; MEASLES-VACCINE; GUINEA-BISSAU; RESPONSES;

D O I：

10.1038/ni.2961

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to its greatest benefit. The World Health Organization has identified investigations into the molecular basis of nonspecific vaccine effects as a research priority.

引用

页码：895 / 899

页数：5

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