Sex differences in gout characteristics: tailoring care for women and men

被引：44

作者：

Harrold, Leslie R. ^{[1
]}

Etzel, Carol J. ^{[2
,3
]}

Gibofsky, Allan ^{[4
]}

Kremer, Joel M. ^{[5
,6
]}

Pillinger, Michael H. ^{[7
]}

Saag, Kenneth G. ^{[8
]}

Schlesinger, Naomi

Terkeltaub, Robert ^{[9
,10
]}

Cox, Vanessa ^{[2
]}

Greenberg, Jeffrey D. ^{[2
,7
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med & Orthoped, 55 Lake Ave North, Worcester, MA 01655 USA

[2] Corrona LLC, Southborough, MA USA

[3] UT MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX USA

[4] Cornell Univ, Hosp Special Surg, Weill Med Coll, New York, NY 10021 USA

[5] Albany Med Coll, Albany, NY 12208 USA

[6] Ctr Rheumatol, Albany, NY USA

[7] NYU, Sch Med, New York, NY USA

[8] Univ Alabama Birmingham, Birmingham, AL USA

[9] Rutgers Robert Wood Johnson Med Sch, New Brunswick, NJ USA

[10] Univ Calif San Diego, VA Med Ctr, San Diego, CA USA

来源：

BMC MUSCULOSKELETAL DISORDERS | 2017年 / 18卷

基金：

美国国家卫生研究院;

关键词：

Gout; Comorbidity; Gender; Quality of Care; CLINICAL SPECTRUM; WEIGHT-LOSS; ARTHRITIS; MANAGEMENT; PROTEIN; HEALTH; FAT;

D O I：

10.1186/s12891-017-1465-9

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Background: To characterize the differences between women and men with gout. Methods: We analyzed a US national cohort of gout patients cared for by rheumatologists. Results: Compared with the 1012 men with gout, women with gout (n = 262) were older (71 vs. 61 years, p < 0. 001) and had a greater burden of comorbid conditions (p < 0.001 for hypertension, diabetes, renal disease and obesity). Risk factors for gout differed with women more often taking diuretics (p < 0.001), while men more frequently had dietary triggers (p < 0.05). Conclusions: The profiles of women and men with gout are markedly different, suggesting a need to tailor treatment recommendations.

引用

页数：6

共 18 条

[1] Febuxostat, a Novel Nonpurine Selective Inhibitor of Xanthine Oxidase [J].

Becker, Michael A. ;

Schumacher, H. Ralph, Jr. ;

Wortmann, Robert L. ;

MacDonald, Patricia A. ;

Palo, William A. ;

Eustace, Denise ;

Vernillet, Laurent ;

Joseph-Ridge, Nancy .

ARTHRITIS AND RHEUMATISM, 2005, 52 (03) :916-923

[2] On the brink of novel therapeutic options for an ancient disease [J].

Bieber, JD ;

Terkeltaub, RA .

ARTHRITIS AND RHEUMATISM, 2004, 50 (08) :2400-2414

[3] Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study [J].

Dessein, PH ;

Shipton, EA ;

Stanwix, AE ;

Joffe, BI ;

Ramokgadi, J .

ANNALS OF THE RHEUMATIC DISEASES, 2000, 59 (07) :539-543

[4]

Edwards N L, 2011, J Med Econ, V14, P10, DOI 10.3111/13696998.2010.540874

[5] Sex differences in gout epidemiology: evaluation and treatment [J].

Harrold, L. R. ;

Yood, R. A. ;

Mikuls, T. R. ;

Andrade, S. E. ;

Davis, J. ;

Fuller, J. ;

Chan, K. A. ;

Roblin, D. ;

Raebel, M. A. ;

Von Worley, A. ;

Platt, R. ;

Saag, K. G. .

ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (10) :1368-1372

[6] High-protein, low-fat diets are effective for weight loss and favorably alter biomarkers in healthy adults [J].

Johnston, CS ;

Tjonn, SL ;

Swan, PD .

JOURNAL OF NUTRITION, 2004, 134 (03) :586-591

[7] 2012 American College of Rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis [J].

Khanna, Dinesh ;

Khanna, Puja P. ;

Fitzgerald, John D. ;

Singh, Manjit K. ;

Bae, Sangmee ;

Neogi, Tuhina ;

Pillinger, Michael H. ;

Merill, Joan ;

Lee, Susan ;

Prakash, Shraddha ;

Kaldas, Marian ;

Gogia, Maneesh ;

Perez-Ruiz, Fernando ;

Taylor, Will ;

Liote, Frederic ;

Choi, Hyon ;

Singh, Jasvinder A. ;

Dalbeth, Nicola ;

Kaplan, Sanford ;

Niyyar, Vandana ;

Jones, Danielle ;

Yarows, Steven A. ;

Roessler, Blake ;

Kerr, Gail ;

King, Charles ;

Levy, Gerald ;

Furst, Daniel E. ;

Edwards, N. Lawrence ;

Mandell, Brian ;

Schumacher, H. Ralph ;

Robbins, Mark ;

Wenger, Neil ;

Terkeltaub, Robert .

ARTHRITIS CARE & RESEARCH, 2012, 64 (10) :1447-1461

[8] Gout and the risk of acute myocardial infarction [J].

Krishnan, Eswar ;

Baker, Joshua F. ;

Furst, Daniel E. ;

Schumacher, H. Ralph .

ARTHRITIS AND RHEUMATISM, 2006, 54 (08) :2688-2696

[9] THE CLINICAL SPECTRUM OF GOUTY-ARTHRITIS IN WOMEN [J].

LALLY, EV ;

HO, G ;

KAPLAN, SR .

ARCHIVES OF INTERNAL MEDICINE, 1986, 146 (11) :2221-2225

[10] FEMALE GOUT - CLINICAL SPECTRUM AND URIC-ACID METABOLISM [J].

PUIG, JG ;

MICHAN, AD ;

JIMENEZ, ML ;

DEAYALA, CP ;

MATEOS, FA ;

CAPITAN, CF ;

DEMIGUEL, E ;

GIJON, JB .

ARCHIVES OF INTERNAL MEDICINE, 1991, 151 (04) :726-732

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