A biodegradable starch hydrogel synthesized via thiol-ene click chemistry

被引：39

作者：

Li, Yangling ^{[1
,2
]}

Tan, Ying ^{[1
]}

Xu, Kun ^{[1
]}

Lu, Cuige ^{[1
]}

Wang, Pixin ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

POLYMER DEGRADATION AND STABILITY | 2017年 / 137卷

基金：

中国国家自然科学基金;

关键词：

Starch; Hydrogel; Biodegradable; Thiol-ene click; ALPHA-AMYLASE; DEGRADATION; DELIVERY; TOUGH; ACID;

D O I：

10.1016/j.polymdegradstab.2016.07.015

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The biodegradable polysaccharide hydrogels have attracted much attention due to its biocompatible and non-toxicity. Herein, we report a starch hydrogel synthesized via thiol-ene click reaction between thiol starch (St-SH) and allyl starch (AS). The swelling behaviors, rheological experiment and biodegradable properties of the obtained hydrogel were investigated in details. The chemical structure of functioned starch was confirmed by H-1-NMR and C-13-NMR. Moreover, the rheological experiment indicated that starch hydrogel possessed high mechanical strength, and its modulus could be manipulated by the thiolene molar ratio. Biodegradation tests revealed that the hydrogel could be biodegradable rapidly in the presence of alpha-amylase. The biodegradation rate could be controlled by the thiol-ene molar ratio or the concentration of alpha-amylase. Degradation kinetics from the hydrogel suggested that the degradation/erosion of starch hydrogel come from a combination of both the surface erosion and diffusion mechanisms. (C) 2016 Published by Elsevier Ltd.

引用

页码：75 / 82

页数：8

共 35 条

[1] Wheat flour enzymatic amylolysis monitored by in situ 1H NMR spectroscopy [J].