Mechanistic insights into a catalyst-free method to construct quinazolinones through multiple oxidative cyclization

被引：24
作者：
Wang, Zhen-zhen [1 ]
Tang, Yu [1 ]
机构：
[1] Tianjin Univ, Key Lab Modern Drug Delivery & High Efficiency, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China
来源：
TETRAHEDRON | 2016年 / 72卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Mechanistic; Catalyst-free; Quinazolinones; Oxidative cyclizatio; ONE-POT SYNTHESIS; BENZYL ALCOHOLS; SUBSTITUTED 4(3H)-QUINAZOLINONES; FACILE SYNTHESIS; DERIVATIVES; EFFICIENT; HETEROCYCLES; ALDEHYDES; WATER; QUINAZOLIN-4(3H)-ONES;
D O I：
10.1016/j.tet.2016.01.027
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel one-pot benign oxidative cyclization of alcohols with 2-aminobenzamides was successfully developed without catalyst to afford the quinazolinones under O-2. This one-pot protocol involved oxidations and cyclizations to construct the skeleton of quinazolinones through possibly three kinds of distinct reaction mechanisms. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1330 / 1336
页数：7
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