Mechanistic insights into a catalyst-free method to construct quinazolinones through multiple oxidative cyclization

被引：24

作者：

Wang, Zhen-zhen ^{[1
]}

Tang, Yu ^{[1
]}

机构：

[1] Tianjin Univ, Key Lab Modern Drug Delivery & High Efficiency, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China

来源：

TETRAHEDRON | 2016年 / 72卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Mechanistic; Catalyst-free; Quinazolinones; Oxidative cyclizatio; ONE-POT SYNTHESIS; BENZYL ALCOHOLS; SUBSTITUTED 4(3H)-QUINAZOLINONES; FACILE SYNTHESIS; DERIVATIVES; EFFICIENT; HETEROCYCLES; ALDEHYDES; WATER; QUINAZOLIN-4(3H)-ONES;

D O I：

10.1016/j.tet.2016.01.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel one-pot benign oxidative cyclization of alcohols with 2-aminobenzamides was successfully developed without catalyst to afford the quinazolinones under O-2. This one-pot protocol involved oxidations and cyclizations to construct the skeleton of quinazolinones through possibly three kinds of distinct reaction mechanisms. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1330 / 1336

页数：7

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