Sustainable hydroxypropyl methylcellulose/xyloglucan/gentamicin films with antimicrobial properties

被引：40
作者：
Kondaveeti, Stalin [1 ]
Damato, Tatiana C. [1 ]
Carmona-Ribeiro, Ana M. [2 ]
Sierakowski, Maria R. [3 ]
Siqueira Petri, Denise Freitas [1 ]
机构：
[1] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, Brazil
[2] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo, Brazil
[3] Univ Fed Parana, BioPol, Curitiba, Parana, Brazil
来源：
CARBOHYDRATE POLYMERS | 2017年 / 165卷
基金：
巴西圣保罗研究基金会;
关键词：
Hydroxypropyl methylcellulose (HPMC); Xyloglucan (XG); Blend films; Crosslinking; Gentamicin sulfate; Antibacterial properties; BLENDED FILMS; PENETRANT DIFFUSION; SWELLABLE POLYMERS; HYDROGEL FILMS; RELEASE; XYLOGLUCAN; CELLULOSE; XANTHAN; DRUG; HEMICELLULOSES;
D O I：
10.1016/j.carbpol.2017.02.066
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Hydroxypropyl methylcellulose (HPMC) and xyloglucan (XG) crosslinked with citric acid over a range of HPMC/XG weight ratios formed sustainable blend films characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, tensile tests, circular dichroism and determination of inhibitory activity against Staphylococcus aureus and Escherichia coli. Both in solution and in the crosslinked films, HPMC chains lost the original ordered conformation upon interacting with XG, giving rise to an entropic gain. The highest values of tensile strength (25 MPa) and Young's modulus (689 MPa) occurred for the 50:50 HPMC/XG blend films. In vitro loading of gentamicin sulfate (GS) in the films amounted to 0.18 +/- 0.05-0.37 +/- 0.05 g of GS per g polymer. At pH 7.4 and 37 degrees C, the GS release kinetics from the films fitted with the Korsmeyer-Peppas model revealed a non-Fickian release mechanism with diffusional coefficient n similar to 0.7. The cross-linked films of HPMC, XG and their blends loaded with GS showed outstanding antibacterial activity against Staphylococcus aureus and Escherichia coli, disclosing their potential for novel biomedical applications. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：285 / 293
页数：9
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