Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome

被引：111
作者：
Au, Christy W. H. [1 ]
Siu, Michelle K. Y. [1 ]
Liao, Xiaoyun [1 ]
Wong, Esther S. Y. [1 ]
Ngan, Hextan Y. S. [2 ]
Tam, Kar Fai [2 ]
Chan, Dominic C. W. [1 ]
Chan, Queeny K. Y. [1 ]
Cheung, Annie N. Y. [1 ]
机构：
[1] Univ Hong Kong, Dept Pathol, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Obstet & Gynaecol, Hong Kong, Hong Kong, Peoples R China
来源：
CANCER LETTERS | 2009年 / 281卷 / 02期
关键词：
TrkB; Ovarian cancer; Cell migration; Invasion; Apoptosis; ENDOTHELIAL GROWTH-FACTOR; GESTATIONAL-TROPHOBLASTIC-DISEASE; HUMAN NEUROBLASTOMA-CELLS; NEUROTROPHIC FACTOR; PREIMPLANTATION EMBRYOS; SURFACE EPITHELIUM; MOLECULAR-BIOLOGY; RETINOIC ACID; TRKB; CARCINOMA;
D O I：
10.1016/j.canlet.2009.02.025
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this report, we demonstrated that overexpression of tropomyosin-related kinase B (TrkB) was associated with shorter survival in ovarian cancer patients. Brain-derived neurotrophic factor (BDNF), the TrkB ligand, induced activation (phosphorylation) of TrkB in a dose dependent manner. Besides demonstrating the effect of BDNF/TrkB pathway in enhancing cancer cell migration and invasion but inhibiting apoptosis, we also report for the first time that exogenous hepatocyte growth factor induced TrkB expression at both mRNA and protein levels as well as phosphorylation. Our findings suggest that BDNF/TrkB pathway is important in ovarian carcinogenesis and TrkB may be a potential therapeutic target for ovarian cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：151 / 161
页数：11
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