P(i-PrNCH2CH2)3N as a Lewis Base Catalyst for the Synthesis of β-Hydroxynitriles Using TMSAN

被引：34

作者：

Wadhwa, Kuldeep ^{[1
]}

Verkade, John G. ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 15期

基金：

美国国家科学基金会;

关键词：

CARBONYL-COMPOUNDS; EFFICIENT PROMOTER; HYDROXY NITRILES; COOPERATIVE CATALYSIS; COUPLING REACTIONS; ACETONITRILE; ALDEHYDES; ACTIVATION; TRIMETHYLSILYLACETONITRILE; PROAZAPHOSPHATRANES;

D O I：

10.1021/jo900814t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Proazaphosphatrane 1a was found to be an efficient catalyst for synthesis of beta-hydroxynitriles via the reaction of trimethylsilylacetonitrile (TMSAN) with aldehydes under mild reaction conditions and typically low catalyst loading (ca. 2 mol%). A variety of functional groups were tolerated, and good to excellent product yields were obtained.

引用

收藏

页码：5683 / 5686

页数：4

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