Lanostane-type C31 triterpenoid derivatives from the fruiting bodies of cultivated Fomitopsis palustris

被引：18

作者：

Zhao, Jinzhi ^{[1
,2
]}

Yang, Yun ^{[1
]}

Yu, Mengyao ^{[3
]}

Yao, Ke ^{[3
]}

Luo, Xia ^{[3
]}

Qi, Huayi ^{[1
]}

Zhang, Guolin ^{[1
]}

Luo, Yinggang ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Biol, 9 Sect 4,Renmin Rd South, Chengdu 610041, Sichuan, Peoples R China

[2] Univ Chinese Acad Sci, 19A Yuguan Rd, Beijing 100049, Peoples R China

[3] Sichuan Acad Chinese Med Sci, Inst Med Fungi, 51 Sect 4,Renmin Rd South, Chengdu 610041, Sichuan, Peoples R China

来源：

PHYTOCHEMISTRY | 2018年 / 152卷

关键词：

Fomitopsis palustris; Fomitopsidaceae; Lanostane; Triterpenoid; Palustrisoic acid; Palustrisolide; Cytotoxicity; PIPTOPORUS-BETULINUS; CYCLOLANOSTANOL XYLOSIDE; BEESIA-CALTHAEFOLIA; SOULIEA-VAGINATA; PORIA-COCOS; FUNGUS; CONSTITUENTS; PINICOLA; LACTONES; STEREOCHEMISTRY;

D O I：

10.1016/j.phytochem.2018.04.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fifteen undescribed and five known lanostane-type C-31 triterpenoid derivatives were isolated from the aqueous EtOH extract of the fruiting bodies of cultivated Fomitopsis palustris. Their structures were identified from the spectroscopic data and chemical degradation studies. The structures of palustrisoic acids A and H were confirmed by X-ray crystallography. Polyporenic acid B showed strong cytotoxicity against the HCT116, A549, and HepG2 cell lines with IC50 values of 8.4, 12.1, and 12.2 mu M, respectively. Palustrisolides A, C, and G displayed weak cytotoxicity. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：10 / 21

页数：12

共 36 条

[1]

ALLEN FH, 1971, TETRAHEDRON LETT, P283

[2] Fomiroid A, a Novel Compound from the Mushroom Fomitopsis nigra, Inhibits NPC1L1-Mediated Cholesterol Uptake via a Mode of Action Distinct from That of Ezetimibe [J].

Chiba, Tomohiro ;

Sakurada, Tsuyoshi ;

Watanabe, Rie ;

Yamaguchi, Kohji ;

Kimura, Yasuhisa ;

Kioka, Noriyuki ;

Kawagishi, Hirokazu ;

Matsuo, Michinori ;

Ueda, Kazumitsu .

PLOS ONE, 2014, 9 (12) :e116162

[3] Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry [J].

De Silva, Dilani D. ;

Rapior, Sylvie ;

Sudarman, Enge ;

Stadler, Marc ;

Xu, Jianchu ;

Alias, S. Aisyah ;

Hyde, Kevin D. .

FUNGAL DIVERSITY, 2013, 62 (01) :1-40

[4] Officimalonic acids A-H, lanostane triterpenes from the fruiting bodies of Fomes officinalis [J].

Han, Jianxin ;

Li, Liya ;

Zhong, Jialiang ;

Tohtaton, Zeynep ;

Ren, Qing ;

Han, Li ;

Huang, Xueshi ;

Yuan, Tao .

PHYTOCHEMISTRY, 2016, 130 :193-200

[5] Secondary metabolites from fungus Fomes cajanderi [J].

He, Jian ;

Feng, Xiao-Zhang ;

Ji, Teng-Fei ;

Lu, Yang ;

Zhao, Bin .

NATURAL PRODUCT RESEARCH, 2006, 20 (06) :598-605

[6] Triterpenoids [J].

Hill, Robert A. ;

Connolly, Joseph D. .

NATURAL PRODUCT REPORTS, 2017, 34 (01) :90-122

[7] Chlorinated Coumarins from the Polypore Mushroom Fomitopsis officinalis and Their Activity against Mycobacterium tuberculosis [J].

Hwang, Chang Hwa ;

Jaki, Birgit U. ;

Klein, Larry L. ;

Lankin, David C. ;

McAlpine, James B. ;

Napolitano, Jose G. ;

Fryling, Nicole A. ;

Franzblau, Scott G. ;

Cho, Sang Hyun ;

Stamets, Paul E. ;

Wang, Yuehong ;

Pauli, Guido F. .

JOURNAL OF NATURAL PRODUCTS, 2013, 76 (10) :1916-1922

[8] OPTICAL ROTATORY DISPERSION .24. LACTONES [J].

JENNINGS, JP ;

KLYNE, W ;

SCOPES, PM .

JOURNAL OF THE CHEMICAL SOCIETY, 1965, (DEC) :7211-&

[9]

Jiang Z., 1977, TETRAHEDRON, V53, P16999

[10] Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus [J].

Kamo, T ;

Asanoma, M ;

Shibata, H ;

Hirota, M .

JOURNAL OF NATURAL PRODUCTS, 2003, 66 (08) :1104-1106

← 1 2 3 4 →