Factors Associated with Respiratory Illness in Children and Young Adults with Cerebral Palsy

被引:39
作者
Blackmore, Amanda Marie [1 ,2 ]
Bear, Natasha [3 ,4 ,5 ]
Blair, Eve [4 ]
Gibson, Noula [1 ,2 ,3 ]
Jalla, Caris [1 ,2 ]
Langdon, Katherine [5 ]
Moshovis, Lisa [1 ,2 ]
Steer, Kellie [6 ]
Wilson, Andrew C. [4 ,7 ,8 ]
机构
[1] Abil Ctr, Therapy Serv, POB 61, Mount Lawley, WA 6929, Australia
[2] Abil Ctr, Hlth Serv, POB 61, Mount Lawley, WA 6929, Australia
[3] Princess Margaret Hosp Children, Physiotherapy, Subiaco, WA, Australia
[4] Univ Western Australia, Telethon Kids Inst, Nedlands, WA 6009, Australia
[5] Princess Margaret Hosp Children, Pediat Rehabil, Subiaco, WA, Australia
[6] Princess Margaret Hosp Children, Perth Childrens Hosp Project, Subiaco, WA, Australia
[7] Princess Margaret Hosp Children, Resp Med, Subiaco, WA, Australia
[8] Univ Western Australia, Sch Paediat & Child Hlth, Crawley, Australia
关键词
GROSS MOTOR FUNCTION; SILENT ASPIRATION; SURVIVAL; PREVALENCE; AUSTRALIA; VICTORIA; SYSTEM; PEOPLE;
D O I
10.1016/j.jpeds.2015.09.064
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective To describe associations between respiratory illness and its potential predictors in children and young adults with cerebral palsy (CP). Study design Cross-sectional survey of self-and caregiver-reported respiratory symptoms for individuals aged up to 26 years with CP. Respiratory illness was indicated by 2 outcomes: (1) >= 1 respiratory hospitalizations in the past year; and (2) >= 2 courses of antibiotics for respiratory symptoms in the past year. ORs were calculated using univariate and multivariate logistic regression. Results There were 551 participants, aged 1-26 years, distributed across all gross motor function classification scale (GMFCS) levels. In univariate analyses, factors significantly associated with respiratory hospitalizations were weekly respiratory symptoms (OR 2.31, 95% CI 1.78-3.00), respiratory symptoms during meals (OR 3.23, 95% CI 1.50-5.80), gastroesophageal reflux (OR 3.01, 95% CI 1.71-5.31), coughing or choking on saliva (OR 4.36, 95% CI 2.38-8.01), current asthma (OR 3.56, 95% CI 1.97-6.42), age (0-3 years) (OR 3.24, 95% CI 1.19-8.80, compared with 13-17 years), seizures (OR 3.45, 95% CI 1.96-6.08), and scoliosis (OR 2.14, 95% CI 1.16-3.97). Nonambulatory individuals (GMFCS IV-V) were at significantly increased risk of hospitalizations only if they had food modifications and/or nasogastric or gastrostomy tube feeds (OR 5.36, 95% CI 2.89-9.96, compared with GMFCS I-III with no food modifications and no tube). All factors, except seizures and scoliosis, were significantly associated with multiple courses of antibiotics in univariate analyses. Conclusions Oromotor dysfunction is strongly associated with respiratory illness in patients with CP.
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收藏
页码:151 / +
页数:8
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