Adiposity, Type 2 Diabetes, and Alzheimer's Disease

被引:172
作者
Luchsinger, Jose A. [1 ,2 ,3 ,4 ]
Gustafson, Deborah R. [5 ,6 ]
机构
[1] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA
[2] Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA
[3] Coll Phys & Surg, Dept Med, Div Gen Med, New York, NY USA
[4] Columbia Univ, Dept Epidemiol, Joseph P Mailman Sch Publ Hlth, New York, NY USA
[5] Univ Gothenburg, Sahlgrenska Acad, Sect Psychiat & Neurochem, Inst Neurosci & Physiol, Gothenburg, Sweden
[6] Med Coll Wisconsin, Dept Family & Community Med, Milwaukee, WI 53226 USA
基金
美国国家卫生研究院; 瑞典研究理事会;
关键词
Adiposity; Alzheimer's disease; cognitive impairment; glucose; hyperinsulinemia; insulin; obesity; overweight; type; 2; diabetes; MILD COGNITIVE IMPAIRMENT; BODY-MASS INDEX; VASCULAR RISK-FACTORS; C-PEPTIDE LEVELS; INSULIN-RESISTANCE; WEIGHT-LOSS; METABOLIC SYNDROME; INCIDENT DEMENTIA; FASTING INSULIN; WAIST CIRCUMFERENCE;
D O I
10.3233/JAD-2009-1022
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This manuscript provides a comprehensive review of the epidemiologic evidence linking the continuum of adiposity and type 2 diabetes (T2D) with Alzheimer's disease (AD). The mechanisms relating adiposity and T2D to AD may include hyperinsulinemia, advanced products of glycosylation, cerebrovascular disease, and products of adipose tissue metabolism. Elevated adiposity in middle age is related to a higher risk of AD but the data on this association in old age is conflicting. Several studies have shown that hyperinsulinemia, a consequence of higher adiposity and insulin resistance, is also related to a higher risk of AD. Hyperinsulinemia is a risk factor for T2D, and numerous studies have shown a relation of T2D with higher AD risk. The implication of these associations is that a large proportion of the world population may be at increased risk of AD given the trends for increasing prevalence of overweight, obesity, hyperinsulinemia, and T2D. However these associations may present a unique opportunity for prevention and treatment of AD. Several studies in the prevention and treatment of T2D are currently conducting, or have planned, cognition ancillary studies. In addition, clinical trials using insulin sensitizers in the treatment or prevention of AD are under way.
引用
收藏
页码:693 / 704
页数:12
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