Exosomes in cancer: Use them or target them?

被引：117
作者：
Bastos, Nuno [1 ,2 ]
Ruivo, Carolina F. [1 ,2 ]
da Silva, Soraia [1 ,2 ]
Melo, Sonia A. [1 ,2 ,3 ]
机构：
[1] Univ Porto, Inst Invest & Inovacao Saude, Portugal i3S, Porto, Portugal
[2] Univ Porto IPATIMUP, Inst Mol Pathol & Immunol, Porto, Portugal
[3] Univ Porto FMUP, Med Fac, Porto, Portugal
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2018年 / 78卷
关键词：
Extracellular vesicles; Exosomes; Cancer; Therapy; BREAST-CANCER; HER2-TARGETED THERAPIES; TUMOR MICROENVIRONMENT; MEDIATED TRANSFER; VESICLE FORMATION; CELLS; SECRETION; BIOGENESIS; MICRORNAS; COMMUNICATION;
D O I：
10.1016/j.semcdb.2017.08.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Exosomes are small extracellular vesicles with a significant role in most processes associated with cancer. On one hand, exosomes role in the different hallmarks of cancer has been widely described, highlighting the urge to understand the potential to target communication mediated by exosomes as a novel therapeutic approach in cancer. On the other hand, exosomes stability in circulation and tumor-targeting capacity shows their applicability in the delivery of anti-cancer molecules. This review will discuss the dual applicability of exosomes in cancer focusing on their usage for therapy improvement, or their targeting to block their supportive role in tumor progression and response to therapy. We highlight the current developments and the strategies used to enhance the potential of exosomes to become clinical partners in the treatment of cancer. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：13 / 21
页数：9
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