Auto-antibodies against type I IFNs in > 10% of critically ill COVID-19 patients: a prospective multicentre study

被引：28

作者：

Arrestier, Romain ^{[1
,2
,3
]}

Bastard, Paul ^{[4
,5
,6
]}

Belmondo, Thibaut ^{[7
]}

Voiriot, Guillaume ^{[8
]}

Urbina, Tomas ^{[9
]}

Luyt, Charles-Edouard ^{[10
,11
]}

Gervais, Adrian ^{[4
,5
,6
]}

Bizien, Lucy ^{[4
,5
,6
]}

Segaux, Lauriane ^{[3
,12
]}

Ben Ahmed, Mariem ^{[5
]}

Bellaiche, Raphael ^{[13
]}

Pham, Tai ^{[14
]}

Ait-Hamou, Zakaria ^{[15
]}

Roux, Damien ^{[16
]}

Clere-Jehl, Raphael ^{[17
]}

Azoulay, Elie ^{[17
]}

Gaudry, Stephane ^{[18
]}

Mayaux, Julien ^{[19
]}

Fage, Nicolas ^{[14
]}

Ait-Oufella, Hafid ^{[9
]}

Moncomble, Elsa ^{[1
,2
]}

Parfait, Melodie ^{[1
]}

Dorgham, Karim ^{[20
]}

Gorochov, Guy ^{[20
,21
]}

Mekontso-Dessap, Armand ^{[1
,2
,3
]}

Canoui-Poitrine, Florence ^{[3
,19
]}

Casanova, Jean-Laurent ^{[4
,5
,6
]}

Hue, Sophie ^{[3
,7
]}

de Prost, Nicolas ^{[1
,2
,3
]}

机构：

[1] Hop Univ Henri Mondor, Hop Henri Mondor, Assistance Publ Hop Paris, Serv Med Intens Reanimat,Serv Reanimat Med, F-94010 Paris, France

[2] Univ Paris Est Creteil, Fac Sante Creteil, Grp Rech Clin CARMAS, F-94010 Paris, France

[3] Univ Paris Est Creteil, IMRB, INSERM, F-94010 Paris, France

[4] Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, Paris, France

[5] Univ Paris, Imagine Inst, Paris, France

[6] Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA

[7] Grp Hospitalo Univ Chenevier Mondor, Assistance Publ Hop Paris AP HP, Dept Hematol & Immunol Biol, F-94010 Paris, France

[8] Hop Tenon, Assistance Publ Hop Paris AP HP, Serv Med Intens Reanimat, Paris, France

[9] Hop St Antoine, Assistance Publ Hop Paris AP HP, Serv Med Intens Reanimat, Paris, France

[10] Sorbonne Univ, Hop Univ Pitie Salpetriere Charles Foix, Assistance Publ Hop Paris AP HP, Serv Med Intens Reanimat, Paris, France

[11] INSERM, Inst Cardiometab & Nutr, UMRS 1166 iCAN, Paris, France

[12] Hop Henri Mondor, Unite Rech Clin AP HP, F-94010 Creteil, France

[13] Hop Univ Henri Mondor, Assistance Publ Hop Paris, Serv Anesthesie Reanimat Chirurg, F-94000 Creteil, France

[14] Hop Bicetre, AP HP, DMU 4 CORREVE Malad Cur & Vaisseaux, Serv Med Intens Reanimat,Grp Rech Clin CARMAS,FHU, Le Kremlin Bicetre, France

[15] Ctr & Univ Paris, Hop Cochin, Assistance Publ Hop Paris AP HP, Serv Med Intens Reanimat, Paris, France

[16] Hop Louis Mourier, AP HP, DMU Esprit, Med Intens Reanimat, F-92700 Colombes, France

[17] Hop St Louis, Assistance Publ Hop Paris, Serv Med Intens & Reanimat, Paris, France

[18] APHP Hop Avicenne, Dept Reanimat Med Chirurg, Bobigny, France

[19] Grp Hosp Pitie Salpetriere, Assistance Publ Hop Paris, Serv Pneumol & Reanimat Med, Paris, France

[20] Sorbonne Univ, Ctr Immunol & Malad Infect CIMI Paris, INSERM, F-75013 Paris, France

[21] Hop La Pitie Salpetriere, Assistance Publ Hop Paris AP HP, Dept Immunol, F-75013 Paris, France

来源：

ANNALS OF INTENSIVE CARE | 2022年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

COVID-19; Interferon; Auto-antibodies; Acute respiratory distress syndrome; IMMUNITY; SCORE;

D O I：

10.1186/s13613-022-01095-5

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: Auto-antibodies (auto-Abs) neutralizing type I interferons (IFN) have been found in about 15% of critical cases COVID-19 pneumonia and less than 1% of mild or asymptomatic cases. Determining whether auto-Abs influence presentation and outcome of critically ill COVID-19 patients could lead to specific therapeutic interventions. Our objectives were to compare the severity at admission and the mortality of patients hospitalized for critical COVID-19 in ICU with versus without auto-Abs.Results: We conducted a prospective multicentre cohort study including patients admitted in 11 intensive care units (ICUs) from Great Paris area hospitals with proven SARS-CoV-2 infection and acute respiratory failure. 925 critically ill COVID-19 patients were included. Auto-Abs neutralizing type I IFN-alpha 2, beta and/or omega were found in 96 patients (10.3%). Demographics and comorbidities did not differ between patients with versus without auto-Abs. At ICU admission, Auto-Abs positive patients required a higher FiO2 (100% (70-100) vs. 90% (60-100), p = 0.01), but were not different in other characteristics. Mortality at day 28 was not different between patients with and without auto-Abs (18.7 vs. 23.7%, p = 0.279). In multivariable analysis, 28-day mortality was associated with age (adjusted odds ratio (aOR) = 1.06 [1.04-1.08], p < 0.001), SOFA score (aOR = 1.18 [1.12-1.23], p < 0.001) and immunosuppression (aOR = 1.82 [1.1-3.0], p = 0.02), but not with the presence of auto-Abs (aOR = 0.69 [0.38-1.26], p = 0.23).Conclusions: In ICU patients, auto-Abs against type I IFNs were found in at least 10% of patients with critical COVID-19 pneumonia. They were not associated with day 28 mortality.

引用

页数：11

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Auto-antibodies against type I IFNs in &gt; 10% of critically ill COVID-19 patients: a prospective multicentre study

Auto-antibodies against type I IFNs in > 10% of critically ill COVID-19 patients: a prospective multicentre study