Expression of neurotrophin-3 mRNA in the rat visual cortex and hippocampus is influenced by environmental conditions

被引：59

作者：

Torasdotter, M ^{[1
]}

Metsis, M ^{[1
]}

Henriksson, BG ^{[1
]}

Winblad, B ^{[1
]}

Mohammed, AH ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT MED CHEM,MOL NEUROBIOL LAB,S-17177 STOCKHOLM,SWEDEN

来源：

NEUROSCIENCE LETTERS | 1996年 / 218卷 / 02期

关键词：

neurotrophin-3; visual cortex; hippocampus; environmental complexity; plasticity; learning; in situ hybridization;

D O I：

10.1016/S0304-3940(96)13127-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Environmental enrichment results in structural changes in the brain. Recent findings indicate involvement of neurotrophins in neuronal plasticity. This study examined the effect of environmental complexity on the levels of neurotrophin-3 (NT-3) mRNA in the rat visual cortex and hippocampus, studied by in situ hybridization. Rats housed in groups in a complex, stimulating environment had significantly higher levels of NT-3 mRNA in the visual cortex and the hippocampus than rats housed in individual cages without stimulating objects. These results indicate a possible role for NT-3 in synaptic plasticity.

引用

页码：107 / 110

页数：4

共 20 条

[11] SELECTIVE LESIONING OF FOREBRAIN NORADRENALINE NEURONS AT BIRTH ABOLISHES THE IMPROVED MAZE-LEARNING PERFORMANCE INDUCED BY REARING IN COMPLEX ENVIRONMENT [J].

MOHAMMED, AK ;

JONSSON, G ;

ARCHER, T .

BRAIN RESEARCH, 1986, 398 (01) :6-10

[12] NEUROTROPHIN-3 ENHANCES NEURITE OUTGROWTH IN CULTURED HIPPOCAMPAL PYRAMIDAL NEURONS [J].

MORFINI, G ;

DITELLA, MC ;

FEIGUIN, F ;

CARRI, N ;

CACERES, A .

JOURNAL OF NEUROSCIENCE RESEARCH, 1994, 39 (02) :219-232

[13] AN INCREASE IN DENDRITIC SPINE DENSITY ON HIPPOCAMPAL CA1 PYRAMIDAL CELLS FOLLOWING SPATIAL-LEARNING IN ADULT-RATS SUGGESTS THE FORMATION OF NEW SYNAPSES [J].

MOSER, MB ;

TROMMALD, M ;

ANDERSEN, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (26) :12673-12675

[14]

Robbins Trevor W., 1995, P703

[15] Psychobiology of plasticity: Effects of training and experience on brain and behavior [J].

Rosenzweig, MR ;

Bennett, EL .

BEHAVIOURAL BRAIN RESEARCH, 1996, 78 (01) :57-65

[16] STRESS AND ANTIDEPRESSANTS DIFFERENTIALLY REGULATE NEUROTROPHIN-3 MESSENGER-RNA EXPRESSION IN THE LOCUS-COERULEUS [J].

SMITH, MA ;

MAKINO, S ;

ALTEMUS, M ;

MICHELSON, D ;

HONG, SK ;

KVETNANSKY, R ;

POST, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (19) :8788-8792

[17] MULTIPLE PROMOTERS DIRECT TISSUE-SPECIFIC EXPRESSION OF THE RAT BDNF-GENE [J].

TIMMUSK, T ;

PALM, K ;

METSIS, M ;

REINTAM, T ;

PAALME, V ;

SAARMA, M ;

PERSSON, H .

NEURON, 1993, 10 (03) :475-489

[18] THE NEUROTROPHINS BDNF, NT-3 AND NT-4/5 PROMOTE SURVIVAL AND MORPHOLOGICAL AND BIOCHEMICAL DIFFERENTIATION OF STRIATAL NEURONS IN-VITRO [J].

VENTIMIGLIA, R ;

MATHER, PE ;

JONES, BE ;

LINDSAY, RM .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1995, 7 (02) :213-222

[19] NEUROTROPHINS REGULATE SEQUENTIAL-CHANGES IN NEUROTROPHIN RECEPTOR EXPRESSION BY SYMPATHETIC NEUROBLASTS [J].

VERDI, JM ;

ANDERSON, DJ .

NEURON, 1994, 13 (06) :1359-1372

[20]

WHITEHOUSE PJ, 1985, CRC CR REV CL NEUROB, V1, P319

← 1 2 →