A core-shell metal-organic-framework (MOF)-based smart nanocomposite for efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells

被引：92

作者：

Cai, Hui-Juan ^{[1
]}

Shen, Ting-Ting ^{[1
]}

Zhang, Jian ^{[2
]}

Shan, Chang-Fu ^{[1
]}

Jia, Jian-Guo ^{[1
]}

Li, Xiang ^{[1
]}

Liu, Wei-Sheng ^{[1
]}

Tang, Yu ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China

[2] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 13期

基金：

中国国家自然科学基金;

关键词：

UP-CONVERSION NANOPARTICLES; HIGHLY EFFICIENT; METHYLENE-BLUE; OXYGEN; MOLECULES; LIGHT;

D O I：

10.1039/c7tb00314e

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Core-shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@ catalase (UCNPs = upconversion nanoparticles; MB = methylene blue; ZIF = zeolitic imidazolate framework) has been constructed for bio-imaging and efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells. The nanoporous MOF shell can prevent aggregation of photosensitizers and serve as an efficient self-sufficient oxygen gas acceptor.

引用

页码：2390 / 2394

页数：5