A core-shell metal-organic-framework (MOF)-based smart nanocomposite for efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells

被引：91

作者：

Cai, Hui-Juan ^{[1
]}

Shen, Ting-Ting ^{[1
]}

Zhang, Jian ^{[2
]}

Shan, Chang-Fu ^{[1
]}

Jia, Jian-Guo ^{[1
]}

Li, Xiang ^{[1
]}

Liu, Wei-Sheng ^{[1
]}

Tang, Yu ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China

[2] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 13期

基金：

中国国家自然科学基金;

关键词：

UP-CONVERSION NANOPARTICLES; HIGHLY EFFICIENT; METHYLENE-BLUE; OXYGEN; MOLECULES; LIGHT;

D O I：

10.1039/c7tb00314e

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Core-shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@ catalase (UCNPs = upconversion nanoparticles; MB = methylene blue; ZIF = zeolitic imidazolate framework) has been constructed for bio-imaging and efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells. The nanoporous MOF shell can prevent aggregation of photosensitizers and serve as an efficient self-sufficient oxygen gas acceptor.

引用

页码：2390 / 2394

页数：5

共 2 条

[1] Biomimetic O2-Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor
Gao, Shutao
Zheng, Pengli
Li, Zhenhua
Feng, Xiaochen
Yan, Weixiao
Chen, Shizhu
Guo, Weisheng
Liu, Dandan
Yang, Xinjian
Wang, Shuxiang
Liang, Xing-Jie
Zhang, Jinchao
BIOMATERIALS, 2018, 178 : 83 - 94
[2] A two-photon excited O2-evolving nanocomposite for efficient photodynamic therapy against hypoxic tumor
Li, Run-Qing
Zhang, Chi
Xie, Bo-Ru
Yu, Wu-Yang
Qiu, Wen-Xiu
Cheng, Han
Zhang, Xian-Zheng
BIOMATERIALS, 2019, 194 : 84 - 93

← 1 →