Metabolic adaptation is an illusion, only present when participants are in negative energy balance

被引:40
作者
Martins, Catia [1 ,2 ,3 ]
Roekenes, Jessica [1 ]
Salamati, Saideh [2 ]
Gower, Barbara A. [3 ]
Hunter, Gary R. [3 ]
机构
[1] Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Clin & Mol Med, Obes Res Grp, Trondheim, Norway
[2] St Olavs Univ Hosp, Clin Surg, Ctr Obes & Innovat ObeCe, Trondheim, Norway
[3] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA
关键词
metabolic adaptation; adaptive thermogenesis; weight regain; resting metabolic rate; weight loss; ADAPTIVE THERMOGENESIS; PHYSICAL-ACTIVITY; WEIGHT-LOSS; MUSCLE GLYCOGEN; OBESE WOMEN; EXPENDITURE; OVERWEIGHT; EXERCISE; REGAIN; WHITE;
D O I
10.1093/ajcn/nqaa220
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: The existence of metabolic adaptation, following weight loss, remains a controversial issue. To our knowledge, no study has evaluated the role of energy balance (EB) in modulating metabolic adaptation. Objectives: The aim of this study was to determine if metabolic adaptation, at the level of resting metabolic rate (RMR), is modulated by participants' EB status. A secondary aim was to investigate if metabolic adaptation was associated with weight regain. Methods: Seventy-one individuals with obesity (BMI: 34.6 +/- 3.4 kg/m(2); age: 45.4 +/- 8.2 y; 33 men) enrolled in a 1000-kcal/d diet for 8 wk, followed by 4 wk of weight stabilization and a 9-mo weight loss maintenance program. Body weight/composition and RMR were measured at baseline, week 9 (W9), week 13 (W13), and 1 y (1Y). Metabolic adaptation was defined as a significantly different (lower or higher) measured compared with predicted RMR. Results: Participants lost on average 14 kg by W9, followed by weight stabilization at W13, and regained 29% of their initial weight loss at 1Y. Metabolic adaptation was found at W9 (-92 +/- 110 kcal/d, P < 0.001) and W13 (-38 +/- 124 kcal/d, P = 0.011) but was not correlated with weight regain. A significant reduction in metabolic adaptation was seen between W9 and W13 (-53 +/- 101 kcal/d, P < 0.001). In a subset of participants who gained weight between W9 and W13 (n = 33). no metabolic adaptation was seen at W13 (-26.8 +/- 1215 kcal/d. P = 0.214). In a subset of participants with data at all time points (n = 45), metabolic adaptation was present at W9 and W13 (-107 +/- 102 kcal/d, P < 0.001 and -49 +/- 128 kcal/d, P= 0.013) but not at 1Y (-7 +/- 129, P = 0.701). Conclusion: After weight loss, metabolic adaptation at the level of RMR is dependent on the EB status of the participants, being reduced to half after a period of weight stabilization. Moreover. metabolic adaptation does not predict weight regain at 1Y follow-up.
引用
收藏
页码:1212 / 1218
页数:7
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