Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

被引：86

作者：

Dedic, Nina ^{[1
]}

Kuehne, Claudia ^{[1
]}

Jakovcevski, Mira ^{[1
]}

Hartmann, Jakob ^{[1
,2
,3
]}

Genewsky, Andreas J. ^{[1
]}

Gomes, Karina S. ^{[1
,4
]}

Anderzhanova, Elmira ^{[1
]}

Poehlmann, Max L. ^{[1
]}

Chang, Simon ^{[1
]}

Kolarz, Adam ^{[1
]}

Vogl, Annette M. ^{[1
]}

Dine, Julien ^{[1
]}

Metzger, Michael W. ^{[1
]}

Schmid, Bianca ^{[1
]}

Almada, Rafael C. ^{[1
]}

Ressler, Kerry J. ^{[2
,3
]}

Wotjak, Carsten T. ^{[1
]}

Grinevich, Valery ^{[5
]}

Chen, Alon ^{[1
]}

Schmidt, Mathias V. ^{[1
]}

Wurst, Wolfgang ^{[6
,7
,8
]}

Refojo, Damian ^{[1
,9
]}

Deussing, Jan M. ^{[1
]}

机构：

[1] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Munich, Germany

[2] Harvard Med Sch, Dept Psychiat, Belmont, MA USA

[3] McLean Hosp, 115 Mill St, Belmont, MA 02178 USA

[4] Univ Estadual Paulista, Lab Neuropsychopharmacol, Araraquara, Brazil

[5] Heidelberg Univ, Schaller Res Grp Neuropeptides, German Canc Res Ctr, Cent Inst Mental Hlth, Heidelberg, Germany

[6] Helmholtz Zentrum Munchen, Inst Dev Genet, Munich, Germany

[7] Tech Univ Munich, Chair Dev Genet, Munich, Germany

[8] German Ctr Neurodegenerat Dis DZNE, Site Munich, Munich, Germany

[9] Max Planck Gesell, Inst Invest Biomed Buenos Aires IBioBA, CONICET, Partner Inst, Buenos Aires, DF, Argentina

来源：

NATURE NEUROSCIENCE | 2018年 / 21卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

VENTRAL TEGMENTAL AREA; CONDITIONED FEAR; MICE; EXPRESSION; STRESS; FOREBRAIN; MEDIATE; EXTINCTION; RECEPTOR; CIRCUIT;

D O I：

10.1038/s41593-018-0151-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

引用

页码：803 / +

页数：8

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