Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

被引：82

作者：

Dedic, Nina ^{[1
]}

Kuehne, Claudia ^{[1
]}

Jakovcevski, Mira ^{[1
]}

Hartmann, Jakob ^{[1
,2
,3
]}

Genewsky, Andreas J. ^{[1
]}

Gomes, Karina S. ^{[1
,4
]}

Anderzhanova, Elmira ^{[1
]}

Poehlmann, Max L. ^{[1
]}

Chang, Simon ^{[1
]}

Kolarz, Adam ^{[1
]}

Vogl, Annette M. ^{[1
]}

Dine, Julien ^{[1
]}

Metzger, Michael W. ^{[1
]}

Schmid, Bianca ^{[1
]}

Almada, Rafael C. ^{[1
]}

Ressler, Kerry J. ^{[2
,3
]}

Wotjak, Carsten T. ^{[1
]}

Grinevich, Valery ^{[5
]}

Chen, Alon ^{[1
]}

Schmidt, Mathias V. ^{[1
]}

Wurst, Wolfgang ^{[6
,7
,8
]}

Refojo, Damian ^{[1
,9
]}

Deussing, Jan M. ^{[1
]}

机构：

[1] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Munich, Germany

[2] Harvard Med Sch, Dept Psychiat, Belmont, MA USA

[3] McLean Hosp, 115 Mill St, Belmont, MA 02178 USA

[4] Univ Estadual Paulista, Lab Neuropsychopharmacol, Araraquara, Brazil

[5] Heidelberg Univ, Schaller Res Grp Neuropeptides, German Canc Res Ctr, Cent Inst Mental Hlth, Heidelberg, Germany

[6] Helmholtz Zentrum Munchen, Inst Dev Genet, Munich, Germany

[7] Tech Univ Munich, Chair Dev Genet, Munich, Germany

[8] German Ctr Neurodegenerat Dis DZNE, Site Munich, Munich, Germany

[9] Max Planck Gesell, Inst Invest Biomed Buenos Aires IBioBA, CONICET, Partner Inst, Buenos Aires, DF, Argentina

来源：

NATURE NEUROSCIENCE | 2018年 / 21卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

VENTRAL TEGMENTAL AREA; CONDITIONED FEAR; MICE; EXPRESSION; STRESS; FOREBRAIN; MEDIATE; EXTINCTION; RECEPTOR; CIRCUIT;

D O I：

10.1038/s41593-018-0151-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

引用

页码：803 / +

页数：8

共 50 条

[1] Strain differences in profiles of dopaminergic neurotransmission in the prefrontal cortex of the BALB/C vs. C57Bl/6 mice: Consequences of stress and afobazole
Anderzhanova, Elmira A.
Baechli, Heidi
Buneeva, Olga A.
Narkevich, Victor B.
Medvedev, Alexei E.
Thoeringer, Christoph K.
Wotjak, Carsten T.
Kudrin, Vladimir S.
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 708 (1-3) : 95 - 104
[2] Projections and interconnections of genetically defined serotonin neurons in mice
Bang, Sun Jung
Jensen, Patricia
Dymecki, Susan M.
Commons, Kathryn G.
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2012, 35 (01) : 85 - 96
[3] Functional and Developmental Identification of a Molecular Subtype of Brain Serotonergic Neuron Specialized to Regulate Breathing Dynamics
Brust, Rachael D.
Corcoran, Andrea E.
Richerson, George B.
Nattie, Eugene
Dymecki, Susan M.
[J]. CELL REPORTS, 2014, 9 (06): : 2152 - 2165
[4] Diversity of Reporter Expression Patterns in Transgenic Mouse Lines Targeting Corticotropin-Releasing Hormone-Expressing Neurons
Chen, Yuncai
Molet, Jenny
Gunn, Benjamin G.
Ressler, Kerry
Baram, Tallie Z.
[J]. ENDOCRINOLOGY, 2015, 156 (12) : 4769 - 4780
[5] Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood
Dedic, N.
Poehlmann, M. L.
Richter, J. S.
Mehta, D.
Czamara, D.
Metzger, M. W.
Dine, J.
Bedenk, B. T.
Hartmann, J.
Wagner, K. V.
Jurik, A.
Almli, L. M.
Lori, A.
Moosmang, S.
Hofmann, F.
Wotjak, C. T.
Rammes, G.
Eder, M.
Chen, A.
Ressler, K. J.
Wurst, W.
Schmidt, M. V.
Binder, E. B.
Deussing, J. M.
[J]. MOLECULAR PSYCHIATRY, 2018, 23 (03) : 533 - 543
[6] Local Optogenetic Induction of Fast (20-40 Hz) Pyramidal-Interneuron Network Oscillations in the In Vitro and In Vivo CA1 Hippocampus: Modulation by CRF and Enforcement of Perirhinal Theta Activity
Dine, Julien
Genewsky, Andreas
Hladky, Florian
Wotjak, Carsten T.
Deussing, Jan M.
Zieglgaensberger, Walter
Chen, Alon
Eder, Matthias
[J]. FRONTIERS IN CELLULAR NEUROSCIENCE, 2016, 10
[7] Inducible gene inactivation in neurons of the adult mouse forebrain
Erdmann, Gitta
Schuetz, Guenther
Berger, Stefan
[J]. BMC NEUROSCIENCE, 2007, 8 (1)
[8] A competitive inhibitory circuit for selection of active and passive fear responses
Fadok, Jonathan P.
Krabbe, Sabine
Markovic, Milica
Courtin, Julien
Xu, Chun
Massi, Lema
Botta, Paolo
Bylund, Kristine
Mueller, Christian
Kovacevic, Aleksandar
Tovote, Philip
Luthi, Andreas
[J]. NATURE, 2017, 542 (7639) : 96 - +
[9] Farley FW, 2000, GENESIS, V28, P106, DOI 10.1002/1526-968X(200011/12)28:3/4<106::AID-GENE30>3.0.CO
[10] 2-T

← 1 2 3 4 5 →