Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer

被引：147

作者：

Jin, Yushen ^{[1
]}

Li, Yanyan ^{[1
]}

Ma, Xibo ^{[3
]}

Zha, Zhengbao ^{[1
]}

Shi, Liangliang ^{[3
]}

Tian, Jie ^{[3
]}

Dai, Zhifei ^{[2
]}

机构：

[1] Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China

[2] Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China

[3] Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China

来源：

BIOMATERIALS | 2014年 / 35卷 / 22期

基金：

中国国家自然科学基金;

关键词：

Photothermal therapy; Photoacoustic imaging; CF imaging; Polypyrrole; Tantalum oxide nanoparticle; GOLD NANOPARTICLES; PHOTOACOUSTIC TOMOGRAPHY; COMPUTED-TOMOGRAPHY; CARBON NANOTUBES; GRAPHENE OXIDE; ULTRASOUND; AGENT; NANOCAGES; NANORODS; THERAPY;

D O I：

10.1016/j.biomaterials.2014.03.086

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A nanotheranostic agent has been readily fabricated by encapsulating tantalum oxide (TaOx) nanoparticles (NPs) into polypyrrole (PPy) NPs via a facile one-step chemical oxidation polymerization for bimodal imaging guided photothermal ablation of tumor. It was proved that the obtained composite nanoparticles (TaOx@PPy NPs) with an average diameter around 45 nm could operate as an efficient bimodal contrast agent to simultaneously enhance X-ray CT and photoacoustic (PA) imaging greatly in vivo. Systemically administered TaOx@PPy NPs could passively accumulate at the tumor site during the blood circulation, which was proved by both CT and PA imaging. In addition, the in vivo therapeutic examinations showed that TaOx@PPy NPs exhibited significant photothermal cytotoxicity under near infrared laser irradiation. The tumor growth inhibition was evaluated to be 66.5% for intravenously injection and 100% for intratumoral injection, respectively. This versatile agent can be developed as a smart and promising nanoplatform that integrates multiple capabilities for both accurate diagnosing and precise locating of cancerous tissue, as well as effective photoablation of tumor. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：5795 / 5804

页数：10

共 52 条

[31] Large-Scale Synthesis of Bioinert Tantalum Oxide Nanoparticles for X-ray Computed Tomography Imaging and Bimodal Image-Guided Sentinel Lymph Node Mapping [J].

Oh, Myoung Hwan ;

Lee, Nohyun ;

Kim, Hyoungsu ;

Park, Seung Pyo ;

Piao, Yuanzhe ;

Lee, Jisoo ;

Jun, Samuel Woojoo ;

Moon, Woo Kyung ;

Choi, Seung Hong ;

Hyeon, Taeghwan .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (14) :5508-5515

[32] Photothermal therapy of tumors in lymph nodes using gold nanorods and near-infrared laser light [J].

Okuno, Tatsuki ;

Kato, Shigeki ;

Hatakeyama, Yuriko ;

Okajima, Junnosuke ;

Maruyama, Shigenao ;

Sakamoto, Maya ;

Mori, Shiro ;

Kodama, Tetsuya .

JOURNAL OF CONTROLLED RELEASE, 2013, 172 (03) :879-884

[33] In vivo carbon nanotube-enhanced non-invasive photoacoustic mapping of the sentinel lymph node [J].

Pramanik, Manojit ;

Song, Kwang Hyun ;

Swierczewska, Magdalena ;

Green, Danielle ;

Sitharaman, Balaji ;

Wang, Lihong V. .

PHYSICS IN MEDICINE AND BIOLOGY, 2009, 54 (11) :3291-3301

[34] Single-Center Phase II Trial of Transarterial Chemoembolization With Drug-Eluting Beads for Patients With Unresectable Hepatocellular Carcinoma Initial Experience in the United States [J].

Reyes, Diane K. ;

Vossen, Josephina A. ;

Kamel, Ihab R. ;

Azad, Nilofer S. ;

Wahlin, Tamara A. ;

Torbenson, Michael S. ;

Choti, Michael A. ;

Geschwind, Jean-Francois H. .

CANCER JOURNAL, 2009, 15 (06) :526-532

[35] Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imaging [J].

Rhyner, Matthew N. ;

Smith, Andrew M. ;

Gao, Xiaohu ;

Mao, Hui ;

Yang, Lily ;

Nie, Shuming .

NANOMEDICINE, 2006, 1 (02) :209-217

[36] Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy [J].

Robinson, Joshua T. ;

Tabakman, Scott M. ;

Liang, Yongye ;

Wang, Hailiang ;

Casalongue, Hernan Sanchez ;

Daniel Vinh ;

Dai, Hongjie .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (17) :6825-6831

[37] Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance [J].

Schwenzer, Nina F. ;

Springer, Fabian ;

Schraml, Christina ;

Stefan, Norbert ;

Machann, Juergen ;

Schick, Fritz .

JOURNAL OF HEPATOLOGY, 2009, 51 (03) :433-445

[38] Near-Infrared Gold Nanocages as a New Class of Tracers for Photoacoustic Sentinel Lymph Node Mapping on a Rat Model [J].

Song, Kwang Hyun ;

Kim, Chulhong ;

Cobley, Claire M. ;

Xia, Younan ;

Wang, Lihong V. .

NANO LETTERS, 2009, 9 (01) :183-188

[39] Noninvasive photoacoustic identification of sentinel lymph nodes containing methylene blue in vivo in a rat model [J].

Song, Kwang Hyun ;

Stein, Erich W. ;

Margenthaler, Julie A. ;

Wang, Lihong V. .

JOURNAL OF BIOMEDICAL OPTICS, 2008, 13 (05)

[40] Hydrophilic Flower-Like CuS Superstructures as an Efficient 980 nm Laser-Driven Photothermal Agent for Ablation of Cancer Cells [J].

Tian, Qiwei ;

Tang, Minghua ;

Sun, Yangang ;

Zou, Rujia ;

Chen, Zhigang ;

Zhu, Meifang ;

Yang, Shiping ;

Wang, Jinglong ;

Wang, Jianhua ;

Hu, Junqing .

ADVANCED MATERIALS, 2011, 23 (31) :3542-+

← 1 2 3 4 5 6 →