Repression of secondary metabolite production by exogenous cAMP in Monascus

被引：20

作者：

Miyake, Tsuyoshi

Zhang, Ming-Yong

Kono, Isato

Nozaki, Nobuyuki

Sammoto, Hiroyuki

机构：

[1] Ind Technol Ctr Okayama Prefectural Prefecture, Okayama 7011296, Japan

[2] Japan Soc Promot Sci, Chiyoda Ku, Tokyo 1028471, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2006年 / 70卷 / 06期

基金：

日本学术振兴会;

关键词：

Monascus; secondary metabolite production; cAMP; repression; mutant MK-1;

D O I：

10.1271/bbb.50686

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cAMP signal pathway controls various biological functions, including secondary metabolism of filamentous fungi. We found that exogenous cAMP represses the production of lovastatin, red pigments, and citrinin in Monascus. Interestingly, a mutant MK-1 with increased lovastatin and red pigments production (Miyake, T., et al., Biosci. Biotechnol. Biochem., 70, 1154-1159 (2006)) was not influenced by cAMP on these productions, indicating that cAMP signaling might be lacking in MK-1.

引用

页码：1521 / 1523

页数：3

共 6 条

[1] LaeA, a regulator of secondary metabolism in Aspergillus spp. [J].