Predictors of sustained clinical response in patients with Beh‡et's disease-related uveitis treated with infliximab and adalimumab

被引：26

作者：

Fabiani, Claudia ^{[1
,2
]}

Vitale, Antonio ^{[3
,4
]}

Rigante, Donato ^{[5
]}

Emmi, Giacomo ^{[6
]}

Lopalco, Giuseppe ^{[7
]}

Sota, Jurgen ^{[3
,4
]}

Vannozzi, Lorenzo ^{[8
]}

di Scala, Gerardo ^{[6
]}

Guerriero, Silvana ^{[9
]}

Orlando, Ida ^{[3
,4
]}

Franceschini, Rossella ^{[2
]}

Capozzoli, Marco ^{[2
]}

Frediani, Bruno ^{[3
,4
]}

Galeazzi, Mauro ^{[3
,4
]}

Iannone, Florenzo ^{[7
]}

Tosi, Gian Marco ^{[2
]}

Cantarini, Luca ^{[3
,4
]}

机构：

[1] Humanitas Clin & Res Ctr, Dept Ophthalmol, Via Manzoni 56, I-20089 Milan, Italy

[2] Univ Siena, Ophthalmol & Neurosurg Dept, Siena, Italy

[3] Univ Siena, Policlin Le Scotte, Res Ctr System Autoinflammatory Dis & Behcets Dis, Viale Bracci 1, I-53100 Siena, Italy

[4] Univ Siena, Policlin Le Scotte, Rheumatol Ophthalmol Collaborat Uveitis Ctr, Rheumatol Unit,Dept Med Sci Surg & Neurosci, Viale Bracci 1, I-53100 Siena, Italy

[5] Univ Cattolica Sacro Cuore, Inst Pediat, Fdn Policlin Univ A Gemelli, Rome, Italy

[6] Univ Florence, Dept Expt & Clin Med, Florence, Italy

[7] Univ Bari, Interdisciplinary Dept Med, Rheumatol Unit, Bari, Italy

[8] Univ Florence, Dept Surg & Translat Med, Eye Clin, Florence, Italy

[9] Univ Bari, Dept Ophthalmol & Otolaryngol, Bari, Italy

来源：

CLINICAL RHEUMATOLOGY | 2018年 / 37卷 / 06期

关键词：

Behcet's disease; Disease activity; Long-termefficacy; Treatment; Uveitis; BEHCETS-DISEASE; ETANERCEPT; EFFICACY; MULTICENTER;

D O I：

10.1007/s10067-018-4092-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To identify clinical variables capable of predicting long-term treatment duration of TNF-alpha inhibition in patients with Behcet's disease (BD)-related uveitis. Demographic, clinical, and therapeutic data were retrospectively collected from BD patients treated with the tumor necrosis factor (TNF)-alpha blockers infliximab and adalimumab. Patients still continuing TNF-alpha inhibitors at 48-month follow-up visits were classified as long-term responders and were statistically compared to patients discontinuing treatment before the 48-month visit. Forty-five patients (75 eyes) were enrolled. Thirty-two patients continued anti-TNF-alpha treatment for more than 48 months; 13 patients discontinued the treatment after a mean time of 12.3 +/- 10.44 months due to lack (61.5%) or loss (38.5%) of efficacy. Baseline value of BD current activity form was the only variable discriminating long- and short-term responsive patients (p = 0.048, OR = 0.656, C.I. 95% 0.433-0.996). Disease activity levels at the start of treatment predict duration of response to monoclonal TNF antagonists in ocular BD.

引用

页码：1715 / 1720

页数：6

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