Synthesis of novel unsaturated bicyclic lactams by ring-closing metathesis

被引：0

作者：

Grossmith, CE ^{[1
]}

Senia, F ^{[1
]}

Wagner, J ^{[1
]}

机构：

[1] Novartis Pharma Corp, CH-4002 Basel, Switzerland

来源：

SYNLETT | 1999年 / 10期

关键词：

bicyclic compounds; metathesis; lactams; ruthenium;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and versatile synthetic method for the preparation of novel unsaturated fused bicyclic lactams is described. The crucial step of the stereoselective approach is the ring-closing metathesis reaction. The 6,5-, 7,5- and 8,5-fused 1-aza-2-oxobicycloalkenes can be obtained in five steps and good overall yield.

引用

收藏

页码：1660 / 1662

页数：3

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