Synthesis, in vitro and in silico evaluation of L-tyrosine containing PPARα/γ dual agonists

A novel series of L-tyrosine derivatives have been reported with potential PPAR alpha/gamma dual agonistic activity. In vitro cell based PPAR alpha/gamma transactivation studies have shown compound 4a and compound 4f to be the most potent PPAR gamma and PPAR alpha activators, respectively. Molecular docking studies performed on these series of compounds have complemented the experimental results and have led to interesting inferences. (c) 2006 Elsevier Ltd. All rights reserved.