Candidate Gene Analysis of Breast Cancer in the Jordanian Population of Arab Descent: A Case-Control Study

被引：22
作者：
Al-Eitan, Laith N. [1 ,2 ]
Jamous, Reem I. [1 ,2 ]
Khasawneh, Rame H. [3 ]
机构：
[1] Jordan Univ Sci & Technol, Dept Appl Biol Sci, Irbid, Jordan
[2] Jordan Univ Sci & Technol, Dept Biotechnol & Genet Engn, Irbid, Jordan
[3] Jordan Royal Med Serv RMS, KHMC, Dept Hematopathol, Amman, Jordan
来源：
CANCER INVESTIGATION | 2017年 / 35卷 / 04期
关键词：
Breast cancer; Jordanian Arabs; genetic association; case-control study; BRCA2; MUTATIONS; DAP-KINASE; SUSCEPTIBILITY GENES; COMMON VARIANTS; FAMILY-HISTORY; PROTEIN-KINASE; RISK; POLYMORPHISMS; TP53; MATRIX-METALLOPROTEINASE-9;
D O I：
10.1080/07357907.2017.1289217
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study aimed to investigate whether there are specific polymorphisms within six genes (BRCA1, BRCA2, TP53, DAPK1, MMP9 promoter, and TOX3) that are associated with breast cancer among the Jordanian population. Sequenom MassARRAY system was used to genotype 17 single nucleotide polymorphisms (SNPs) within these genes in 230 Jordanian breast cancer patients and 225 healthy individuals. Three SNPs (MMP9 (rs6065912), TOX3 (rs1420546), and DAPK1 (rs11141901) were found to be significantly associated with an increased risk of breast cancer (p < .05). This study is the first to provide evidence that genetic variation in MMP9, TOX3, and DAPK1 genes contribute to the development of breast cancer in the Jordanian population.
引用
收藏
页码：256 / 270
页数：15
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