The copper-catalyzed N-arylation of indoles

被引：582

作者：

Antilla, JC ^{[1
]}

Klapars, A ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 39期

关键词：

D O I：

10.1021/ja027433h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general method for the N-arylation of indoles using catalysts derived from Cul and trans-1,2-cyclohexanediamine (1a), trans-N,N'-dimethyl-1,2-cyclohexanediamine (2a), or N,N'-dimethyl-ethylenediamine (3) is reported. N-Arylindoles can be produced in high yield from the coupling of an aryl iodide or aryl bromide with a variety of indoles.

引用

页码：11684 / 11688

页数：5

共 37 条

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