N-H insertion reactions of rhodium carbenoids .1. Preparation of alpha-amino acid and alpha-aminophosphonic acid derivatives

被引：77
作者：
Aller, E
Buck, RT
Drysdale, MJ
Ferris, L
Haigh, D
Moody, CJ
Pearson, ND
Sanghera, JB
机构：
[1] LOUGHBOROUGH UNIV TECHNOL,DEPT CHEM,LOUGHBOROUGH LE11 3TU,LEICS,ENGLAND
[2] GLAXO WELLCOME RES & DEV LTD,MED RES CTR,STEVENAGE SG1 2NY,HERTS,ENGLAND
[3] SMITHKLINE BEECHAM PHARMACEUT,EPSOM KT18 5XQ,SURREY,ENGLAND
[4] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AL,SURREY,ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1996年 / 24期
关键词：
D O I：
10.1039/p19960002879
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Rhodium(II) acetate-catalysed decomposition of diazophenylacetates 1 and 3 in the presence of a range of N-H compounds results in an N-H insertion reaction of the intermediate carbenoids and formation of N-substituted phenylglycine derivatives 2 and 4. The corresponding reactions of dimethyl alpha-diazobenzylphosphonate 5 constitute a simple route to aminophosphonates 6.
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页码：2879 / 2884
页数：6
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