68Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients

被引：104

作者：

Sathekge, Mike ^{[1
,2
]}

Lengana, Thabo ^{[1
,2
]}

Modiselle, Moshe ^{[1
,2
]}

Vorster, Mariza ^{[1
,2
]}

Zeevaart, JanRijn ^{[1
,2
]}

Maes, Alex ^{[1
,2
,3
]}

Ebenhan, Thomas ^{[1
,2
]}

Van de Wiele, Christophe ^{[1
,2
,4
]}

机构：

[1] Univ Pretoria, Dept Nucl Med, Private Bag X169, ZA-0001 Pretoria, South Africa

[2] Steve Biko Acad Hosp, Private Bag X169, ZA-0001 Pretoria, South Africa

[3] AZ Groeninge, Dept Nucl Med, Kortrijk, Belgium

[4] Univ Ghent, Dept Radiol & Nucl Med, Ghent, Belgium

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2017年 / 44卷 / 04期

关键词：

Ga-68-PSMA; PET/CT; Breast cancer; POSITRON-EMISSION-TOMOGRAPHY; ADVANCED SOLID TUMORS; FACTOR RECEPTOR 2; PROSTATE-CANCER; PSMA EXPRESSION; FDG PET; ANGIOGENESIS; METASTASES; THERAPY;

D O I：

10.1007/s00259-016-3563-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

To report on imaging findings using Ga-68-PSMA-HBED-CC PET in a series of 19 breast carcinoma patients. Ga-68-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging examinations and analyzed as to lesion location and progesterone receptor status. Out of 81 tumor lesions identified, 84% were identified on Ga-68-PSMA-HBED-CC PET. Ga-68-PSMA-HBED-CC SUVmean values of distant metastases proved significantly higher (mean, 6.86, SD, 5.68) when compared to those of primary or local recurrences (mean, 2.45, SD, 2.55, p = 0.04) or involved lymph nodes (mean, 3.18, SD, 1.79, p = 0.011). SUVmean values of progesterone receptor-positive lesions proved not significantly different from progesterone receptor-negative lesions. SUV values derived from FDG PET/CT, available in seven patients, and Ga-68-PSMA-HBED-CC PET/CT imaging proved weakly correlated (r = 0.407, p = 0.015). Ga-68-PSMA-HBED-CC PET/CT imaging in breast carcinoma confirms the reported considerable variation of PSMA expression on human solid tumors using immunohistochemistry.

引用

页码：689 / 694

页数：6

共 27 条

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