CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study

被引：89

作者：

Ewers, Michael ^{[1
]}

Mattsson, Niklas ^{[2
,3
]}

Minthon, Lennart ^{[4
,5
]}

Molinuevo, Jose L. ^{[6
,7
]}

Antonell, Anna ^{[6
,7
]}

Popp, Julius ^{[8
,9
]}

Jessen, Frank ^{[8
]}

Herukka, Sanna-Kaisa ^{[10
,11
]}

Soininen, Hilka ^{[10
,11
]}

Maetzler, Walter ^{[12
,13
]}

Leyhe, Thomas ^{[14
]}

Buerger, Katharina ^{[1
]}

Taniguchi, Miyako ^{[15
]}

Urakami, Katsuya ^{[16
]}

Lista, Simone ^{[17
,18
,19
,20
]}

Dubois, Bruno ^{[19
,20
]}

Blennow, Kaj ^{[3
]}

Hampel, Harald ^{[17
,18
,19
,20
]}

机构：

[1] Univ Munich, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Bayern, Germany

[2] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA

[3] Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Sahlgrenska Univ Hosp,Inst Neurosci & Physiol, Molndal, Sweden

[4] Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden

[5] Malmo Univ Hosp, Neuropsychiat Clin, Malmo, Sweden

[6] ICN Hosp Clin Univ, Alzheimers Dis & Cognit Disorders Unit, Neurol Serv, Barcelona, Spain

[7] Pasqual Maragall Fdn, Barcelona, Spain

[8] Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Nordrhein Westf, Germany

[9] Univ Lausanne Hosp, Dept Psychiat, Lausanne, Waadt, Switzerland

[10] Univ Eastern Finland, Dept Neurol, Kuopio, Finland

[11] Kuopio Univ Hosp, SF-70210 Kuopio, Finland

[12] Univ Tubingen, Ctr Neurol, Dept Neurodegenerat, Hertie Inst Clin Brain Res, Tubingen, Germany

[13] German Ctr Neurodegenerat Dis, DZNE, Tubingen, Germany

[14] Univ Hosp, Dept Psychiat & Psychotherapy, Tubingen, Germany

[15] Psychiat Univ Hosp, Ctr Old Age Psychiat, Basel, Switzerland

[16] Tottori Univ, Fac Med, Dept Regulat Biol, Sch Hlth Sci, Yonago, Tottori 683, Japan

[17] AXA Res Fund, Paris, France

[18] UPMC, Paris, France

[19] Univ Paris 06, Sorbonne Univ, Inst Memoire & Maladie Alzheimer, Paris, France

[20] Hop La Pitie Salpetriere, Inst Cerveau & Moelle Epiniere ICM, Dept Neurol, Paris, France

来源：

ALZHEIMERS & DEMENTIA | 2015年 / 11卷 / 11期

关键词：

Biomarker; Cerebrospinal fluid; CSF; Differential diagnosis; Classification; Dementia; Alzheimer's disease; Vascular dementia; Lewy body dementia; Fronto-temporal dementia; CEREBROSPINAL-FLUID BIOMARKERS; MILD COGNITIVE IMPAIRMENT; PHOSPHORYLATED-TAU; VASCULAR DEMENTIA; LEWY BODIES; CRITERIA; BETA-AMYLOID((1-42)); VALIDATION; GUIDELINES; PATHOLOGY;

D O I：

10.1016/j.jalz.2014.12.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: The aim of this study was to test the diagnostic value of cerebrospinal fluid (CSF) beta-amyloid (A beta(1-42)), phosphorylated tau, and total tau (tau) to discriminate Alzheimer's disease (AD) dementia from other forms of dementia. Methods: A total of 675 CSF samples collected at eight memory clinics were obtained from healthy controls, AD dementia, subjective memory impairment, mild cognitive impairment, vascular dementia, Lewy body dementia (LBD), fronto-temporal dementia (FTD), depression, or other neurological diseases. Results: CSF A beta(1-42) showed the best diagnostic accuracy among the CSF biomarkers. At a sensitivity of 85%, the specificity to differentiate AD dementia against other diagnoses ranged from 42% (for LBD, 95% confidence interval or CI 5 32-62) to 77% (for FTD, 95% CI 5 62-90). Discussion: CSF A beta 1-42 discriminates AD dementia from FTD, but shows significant overlap with other non-AD forms of dementia, possibly reflecting the underlying mixed pathologies. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：1306 / 1315

页数：10

共 51 条

[1]

[Anonymous], 1994, J Neurol Neurosurg Psychiatry, V57, P416

[2]

[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th

[3] Validation of amyloid-β peptides in CSF diagnosis of neurodegenerative dementias [J].

Bibl, M. ;

Mollenhauer, B. ;

Lewczuk, P. ;

Esselmann, H. ;

Wolf, S. ;

Trenkwalder, C. ;

Otto, M. ;

Stiens, G. ;

Ruether, E. ;

Kornhuber, J. ;

Wiltfang, J. .

MOLECULAR PSYCHIATRY, 2007, 12 (07) :671-680

[4]

Bjerke M, 2010, INT J ALZHEIMERS DIS, V2010

[5] Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease [J].

Blennow, Kaj ;

Dubois, Bruno ;

Fagan, Anne M. ;

Lewczuk, Piotr ;

de Leon, Mony J. ;

Hampel, Harald .

ALZHEIMERS & DEMENTIA, 2015, 11 (01) :58-69

[6] Cerebrospinal fluid and plasma biomarkers in Alzheimer disease [J].

Blennow, Kaj ;

Hampel, Harald ;

Weiner, Michael ;

Zetterberg, Henrik .

NATURE REVIEWS NEUROLOGY, 2010, 6 (03) :131-144

[7] CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease [J].

Buerger, Katharina ;

Ewers, Michael ;

Pirttila, Tuula ;

Zinkowski, Raymond ;

Alafuzoff, Irina ;

Teipel, Stefan J. ;

DeBernardis, John ;

Kerkman, Daniel ;

McCulloch, Cheryl ;

Soininen, Hilkka ;

Hampel, Harald .

BRAIN, 2006, 129 :3035-3041

[8] Cerebrospinal fluid tau and β-amyloid -: How well do these biomarkers reflect autopsy-confirmed dementia diagnoses? [J].

Clark, CM ;

Xie, S ;

Chittams, J ;

Ewbank, D ;

Peskind, E ;

Galasko, D ;

Morris, JC ;

McKeel, DW ;

Farlow, M ;

Weitlauf, SL ;

Quinn, J ;

Kaye, J ;

Knopman, D ;

Arai, H ;

Doody, RS ;

DeCarli, C ;

Leight, S ;

Lee, VMY ;

Trojanowski, JQ .

ARCHIVES OF NEUROLOGY, 2003, 60 (12) :1696-1702

[9] Research criteria for the diagnosis of Alzheimer"s disease: revising the NINCDS-ADRDA criteria [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Dekosky, Steven T. ;

Barberger-Gateau, Pascale ;

Cummings, Jeffrey ;

Delocourte, Andre ;

Galasko, Douglas ;

Gauthier, Serge ;

Jicha, Gregory ;

Meguro, Kenichi ;

O'Brien, John ;

Pasquier, Florence ;

Robert, Philippe ;

Rossor, Martin ;

Solloway, Steven ;

Stern, Yaakov ;

Visser, Pieter J. ;

Scheltens, Philip .

LANCET NEUROLOGY, 2007, 6 (08) :734-746

[10] Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Hampel, Harald ;

Molinuevo, Jose Luis ;

Blennow, Kaj ;

Dekosky, Steven T. ;

Gauthier, Serge ;

Selkoe, Dennis ;

Bateman, Randall ;

Cappa, Stefano ;

Crutch, Sebastian ;

Engelborghs, Sebastiaan ;

Frisoni, Giovanni B. ;

Fox, Nick C. ;

Galasko, Douglas ;

Habert, Marie-Odile ;

Jicha, Gregory A. ;

Nordberg, Agneta ;

Pasquier, Florence ;

Rabinovici, Gil ;

Robert, Philippe ;

Rowe, Christopher ;

Salloway, Stephen ;

Sarazin, Marie ;

Epelbaum, Stephane ;

de Souza, Leonardo C. ;

Vellas, Bruno ;

Visser, Pieter J. ;

Schneider, Lon ;

Stern, Yaakov ;

Scheltens, Philip ;

Cummings, Jeffrey L. .

LANCET NEUROLOGY, 2014, 13 (06) :614-629

← 1 2 3 4 5 6 →